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  4. A non-inferiority test for diagnostic accuracy based on the paired partial areas under ROC curves
 
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A non-inferiority test for diagnostic accuracy based on the paired partial areas under ROC curves

Journal
Statistics in Medicine
Journal Volume
27
Journal Issue
10
Pages
1762-1776
Date Issued
2008
Author(s)
Li, C.-R.
CHEN-TUO LIAO  
JEN-PEI LIU  
DOI
10.1002/sim.3121
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-42449109594&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/338609
Abstract
Non-inferiority is a reasonable approach to assessing the diagnostic accuracy of a new diagnostic test if it provides an easier administration or reduces the cost. The area under the receiver operating characteristic (ROC) curve is one of the common measures for the overall diagnostic accuracy. However, it may not differentiate the various shapes of the ROC curves with different diagnostic significances. The partial area under the ROC curve (PAUROC) may present an alternative that can provide additional and complimentary information for some diagnostic tests which require false-positive rate that does not exceed a certain level. Non-parametric and maximum likelihood methods can be used for the non-inferiority tests based on the difference in paired PAUROCs. However, their performance has not been investigated in finite samples. We propose to use the concept of generalized p-value to construct a non-inferiority test for diagnostic accuracy based on the difference in paired PAUROCs. Simulation results show that the proposed non-inferiority test not only adequately controls the size at the nominal level but also is uniformly more powerful than the non-parametric methods. The proposed method is illustrated with a numerical example using published data. Copyright ? 2007 John Wiley & Sons, Ltd.
Subjects
Generalized confidence interval; Generalized p-value; Maximum likelihood method; Non-parametric method; Sensitivity; Specificity
SDGs

[SDGs]SDG3

Other Subjects
CA 125 antigen; CA 19-9 antigen; article; controlled study; diagnostic accuracy; diagnostic test; false positive result; human; major clinical study; mathematical analysis; maximum likelihood method; nonparametric test; normal distribution; pancreas cancer; process model; receiver operating characteristic; sample size; statistical significance; Computer Simulation; Confidence Intervals; Diagnostic Tests, Routine; Humans; Likelihood Functions; Male; Pancreatic Neoplasms; Predictive Value of Tests; ROC Curve; Statistics, Nonparametric
Type
journal article

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