A convenient method for the selective esterification of amino-alcohols
Journal
Synthetic Communications
Journal Volume
8
Journal Issue
5
Pages
327-333
Date Issued
1978
Author(s)
Chong, Y.H.
Abstract
Abstract Esters of amino-alcohols have long been considered as important biologically active compounds1 and as intermediates for the synthesis of pharmaceutically significant materials2. This ester function can also serve as protective group for the hydroxyl group of amino-alcohols. In addition, unlike other protective groups3 which do not block amines either, the ester is stable in acidic medium and can readily be removed under very mild condition4. Several examples of selective o-acetylation of amino alcohols where the maine function is protected as the salt are found in the literature5. We have attempted to use these methods to synthesize several biologically interest armatic esters of amino alcohols. None of these procedures, however, gave the desired product in reasonable yields. We now wish to describe a convenient procedure to selectively prepare amino esters from amino alcohols.
Type
journal article