|Title:||Delineation of an oral cancer lesion with swept-source optical coherence tomography||Authors:||Tsai, M.-T.
|Issue Date:||2008||Journal Volume:||13||Journal Issue:||4||Source:||Journal of Biomedical Optics||Abstract:||
We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8μm in free space and system sensitivity of 108dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze the lateral variation of A-scan profiles to show two parameters of SS-OCT signal for delineating an oral cancer lesion. One of the parameters is the decay constant in the exponential fitting of the SS-OCT signal intensity along depth. This decay constant decreases as the A-scan point moves laterally across the margin of a lesion. The other parameter is the standard deviation of the SS-OCT signal intensity fluctuation in an A-scan. This parameter increases significantly when the A-scan point is moved across the transition region between the normal and abnormal portions. Such parameters are useful for determining the margins of oral cancer. ? 2008 Society of Photo-Optical Instrumentation Engineers.
|DOI:||10.1117/1.2960632||SDG/Keyword:||Abnormal tissues; Axial resolutions; biomedical optics; Coherent optical systems; Decay constants; Ex vivo imaging; Exponential fitting; Free space; Lateral variations; Oral cancer; Point moves; Signal intensities; Standard deviation; Swept source; System sensitivity; Transition regions; Two parameter; Optical systems; Tissue; Tomography; Diseases; algorithm; article; artificial intelligence; automated pattern recognition; computer assisted diagnosis; human; image enhancement; instrumentation; methodology; mouth tumor; optical coherence tomography; pathology; reproducibility; sensitivity and specificity; Algorithms; Artificial Intelligence; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Mouth Neoplasms; Pattern Recognition, Automated; Reproducibility of Results; Sensitivity and Specificity; Tomography, Optical Coherence
|Appears in Collections:||電機工程學系|
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