https://scholars.lib.ntu.edu.tw/handle/123456789/346572
標題: | Red mold dioscorea has a greater antihypertensive effect than traditional red mold rice in spontaneously hypertensive rats | 作者: | TZU-MING PAN | 關鍵字: | γ-aminobutyric acid; Angiotensin-l-converting enzyme; Antihypertensive effect; Diastolic blood pressure; Monascus; Red mold dioscorea; Red mold rice; Spontaneously hypertensive rats; Systolic blood pressure | 公開日期: | 2009 | 卷: | 57 | 期: | 11 | 起(迄)頁: | 5035-5041 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | The aim of this study is to investigate the antihypertensive effects of red mold rice (RMR) and red mold dioscorea (RMD) by low-dose oral administration to spontaneously hypertensive rats (SHRs). A single oral dose of 1-fold RMD (150 mg/kg) significantly (p < 0.05) decreased systolic blood pressure (SBP) and diastolic blood pressure (DBP) after 8 h of administration, but RMR showed no significant effect. During the chronic oral administration of 1-fold RMR (150 mg/kg), 0.5-fold RMD, 1-fold RMD, and 5-fold RMD to SHRs for 8 weeks, the increase of blood pressure was slowed significantly. The results indicated that only a 0.5-fold dose of RMD was able to significantly decrease both SBP and DBP. A 1-fold RMD showed a greater antihypertensive effect than 1-fold RMR, and both RMR and RMD can improve the vascular elastin structure remodeling. In comparison to RMR, RMD contained a higher amount of γ-aminobutyric acid (GABA) and anti-inflammatory yellow pigments (monascin and ankaflavin). Moreover, RMD also exhibited higher angiotensin-l-converting enzyme (ACE) inhibitory activity than RMR. These results suggest that RMD has greater antihypertensive bioavailability. ? 2009 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-67149116804&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/346572 |
DOI: | 10.1021/jf900349v | SDG/關鍵字: | antihypertensive agent; plant extract; animal; article; blood pressure; chemistry; comparative study; disease model; drug effect; human; hypertension; male; metabolism; microbiology; Monascus; pathophysiology; rat; rice; spontaneously hypertensive rat; yam; Animals; Antihypertensive Agents; Blood Pressure; Dioscorea; Disease Models, Animal; Humans; Hypertension; Male; Monascus; Oryza sativa; Plant Extracts; Rats; Rats, Inbred SHR; Dioscorea; Dioscorea alata; Monascus; Rattus |
顯示於: | 生化科技學系 |
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