https://scholars.lib.ntu.edu.tw/handle/123456789/347103
標題: | Involvement of p29 in DNA damage responses and Fanconi anemia pathway | 作者: | Chu, Po-Chen Wang, Tao-Yeuan Lu, Yen-Ta Chou, Chuan-Kai Yang, Yuh-Cheng MAU-SUN CHANG |
公開日期: | 2009 | 卷: | 30 | 期: | 10 | 起(迄)頁: | 1710 - 1716 | 來源出版物: | Carcinogenesis | 摘要: | Human p29 is a chromatin-associated protein and the silencing of p29 expression increases cell population in G1 phase and decreases phosphorylation levels of Chk1 and Chk2 in response to UV treatment. To further characterize the function of p29, U2OS and Fanconi anemia complementation group G (FA-G) cells with constitutive p29 expression have been established. Analyses of these cells identified increased phosphorylation levels of Chk1 and Chk2, which were accompanied by elevated amounts of chromatin-associated Mre11-Rad50-Nbs1 complex and ATR-IP. Monoubiquitination of the FA ID complex was restored in p29 stably expressing FA-G cells. Moreover, lower tumor incidence was observed in mp29 transgenic mice after UV irradiation. These results suggest the involvement of p29 in the DNA damage responses and Fanconi anemia pathway. ? The Author 2009. Published by Oxford University Press. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-70349996472&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/347103 |
ISSN: | 14602180 | DOI: | 10.1093/carcin/bgp204 | SDG/關鍵字: | ATM protein; ATR protein; checkpoint kinase 1; checkpoint kinase 2; Fanconi anemia protein; Mre11 protein; nibrin; nuclear protein; protein p29; Rad50 protein; unclassified drug; animal tissue; article; cancer cell culture; cancer incidence; carcinogenesis; controlled study; DNA damage; DNA repair; human; human cell; mouse; newborn; nonhuman; nucleotide sequence; priority journal; protein analysis; protein expression; protein function; protein localization; protein phosphorylation; protein protein interaction; transgenic mouse; ubiquitination; ultraviolet irradiation; Animals; Apoptosis; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Hela Cells; Humans; Mice; Mice, Transgenic; Phosphorylation; Protein Kinases; Protein-Serine-Threonine Kinases; RNA, Small Interfering; Ubiquitin; Ultraviolet Rays |
顯示於: | 生化科學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。