https://scholars.lib.ntu.edu.tw/handle/123456789/348438
標題: | Three new eudesmanoids from the Formosan soft coral Nephthea erecta | 作者: | Cheng, S.-Y. Wang, S.-K. Wen, Z.-H. CHANG-FENG DAI Duh, C.-Y. |
關鍵字: | Anti-inflammatory activity; Cytotoxicity; Eudesmanoids; Nephthea erecta; RAW 264.7 macrophages; Tri-nor-eudesmane | 公開日期: | 2009 | 卷: | 11 | 期: | 11 | 起(迄)頁: | 967-973 | 來源出版物: | Journal of Asian Natural Products Research | 摘要: | Chemical investigations on the organic extract of the Formosan soft coral Nephthea erecta led to the isolation of two new eudesmanoids, (4R*,5S*,6Z,10R*)-8-oxo-eudesm-6-en-5α,11-diol (1) and (6E,10R)-4,5-dioxo-11-methoxy-eudesm-6-ene (2), together with one new tri-nor-eudesmane sesquiterpenoid, (4S*,5E,10R*)-7-oxo-tri-nor- eudesm-5-en-4β-ol (3). The structures of metabolites 1-3 were elucidated through extensive spectroscopic analyses and by comparison with those reported in the literature. The anti-inflammatory activity using RAW 264.7 macrophages and their cytotoxicity against selected cancer cells of 1-3 were evaluated in vitro. ? 2009 Taylor & Francis. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-77949611758&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/348438 |
DOI: | 10.1080/10286020903282806 | SDG/關鍵字: | 4,5 dioxo 11 methoxyeudesm 6 ene; 7 oxotrinoreudesm 5 en 4 beta ol; 8 oxoeudesm 6 en 5 alpha, 11 diol; sesquiterpenoid; unclassified drug; antiinflammatory activity; article; cancer cell; carbon nuclear magnetic resonance; chemical structure; coral; cytotoxicity; extract; in vitro study; macrophage; metabolite; Nephthea erecta; nonhuman; proton nuclear magnetic resonance; spectroscopy; Taiwan; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Sesquiterpenes, Eudesmane; Stereoisomerism; Alcyonacea; Nephthea |
顯示於: | 海洋研究所 |
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