https://scholars.lib.ntu.edu.tw/handle/123456789/350006
標題: | Efficient near-IR hyperthermia and intense nonlinear optical imaging contrast on the gold nanorod-in-shell nanostructures | 作者: | Hu, K.-W. Liu, T.-M. Chung, K.-Y. Huang, K.-S. Hsieh, C.-T. Sun, C.-K. Yeh, C.-S. CHI-KUANG SUN |
公開日期: | 2009 | 卷: | 131 | 期: | 40 | 起(迄)頁: | 14186-14187 | 來源出版物: | Journal of the American Chemical Society | 摘要: | (Figure Presented) New gold nanorod (Au NR)-in-shell nanostructures were developed to be more efficacious than Au NRs in near-IR (NIR) hyperthermia and nonlinear optical imaging contrast. Au NR-in-shell nanostructures are composed of an intact Au NR in a Au/Ag nanoshell. These nanostructures have a broad, intense absorption band that extends from 400 nm to 900 nm in the NIR. They are more efficient and efficacious than Au NRs with respect to in vitro hypothermia performance. Au NR-in-shell-labeled cancer cells were destroyed using continuous-wave NIR radiation with 50% less laser power than needed for Au NRs. Noticeably, the area of the destroyed cells was significantly larger than the size of the laser irradiation beam; in contrast, the destroyed area was usually restricted to the size of the laser beam spot when Au NRs were used. With their extraordinarily broad and strong surface plasmon resonance band, Au NR-in-shell nanostructures efficiently augmented several multiphoton nonlinear processes as well. The multiphoton emission spectrum covered almost the entire visible wavelength. The yield of the multiphoton signals of Au NR-in-shell nanostructures was on average 55 times larger than that of Au NRs. In vitro images of cancer cells targeted by Au NR-in-shell nanostructures revealed a stronger multiphoton contrast than those targeted by Au NRs. ? 2009 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-70349912553&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/350006 |
DOI: | 10.1021/ja9062772 | SDG/關鍵字: | Absorption band; Cancer cells; Continuous waves; Gold nanorod; In-shell; In-vitro; Laser irradiations; Laser power; Multi-photon emission; Multiphoton signals; Multiphotons; Nanoshells; Near-IR; Nonlinear optical imaging; Nonlinear process; Surface plasmons; Visible wavelengths; Cells; Emission spectroscopy; Infrared devices; Lasers; Multiphoton processes; Nanorods; Optical image storage; Surface plasmon resonance; Shells (structures); gold nanoparticle; nanorod; article; cancer cell; controlled study; human; human cell; hyperthermic therapy; laser; multiphoton microscopy; near infrared reflectance spectroscopy; surface plasmon resonance; synthesis; Biocompatible Materials; Cell Line, Tumor; Gold; Humans; Hyperthermia, Induced; Image Processing, Computer-Assisted; Infrared Rays; Metal Nanoparticles; Nonlinear Dynamics; Surface Plasmon Resonance |
顯示於: | 電機工程學系 |
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