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  4. Effects of interpolation methods in spatial normalization of diffusion tensor imaging data on group comparison of fractional anisotropy
 
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Effects of interpolation methods in spatial normalization of diffusion tensor imaging data on group comparison of fractional anisotropy

Journal
Magnetic Resonance Imaging
Journal Volume
27
Journal Issue
5
Pages
681-690
Date Issued
2009
Author(s)
Chao, T.-C.
Chou, M.-C.
Yang, P.
Wu, M.-T.
HSIAO-WEN CHUNG  
DOI
10.1016/j.mri.2008.09.004
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-67349135983&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/350382
Abstract
This study investigated the effects on the measurement of fractional anisotropy (FA) during interpolation of diffusion tensor images in spatial normalization, which is required for voxel-based statistics. Diffusion tensor imaging data were obtained from nine male patients with attention deficit/hyperactivity disorder and nine age-matched control subjects. Regions of interest were selected from the genu of corpus callosum (GCC) and the right anterior corona radiata (RACR), with FA values measured before and after spatial normalization using two interpolation algorithms: linear and rotationally linear. Computer simulations were performed to verify the experimental findings. Between-group difference in FA was observed in the GCC and RACR before spatial normalization (P<.00001). Interpolation reduced the measured FA values significantly (P<.00001 for both algorithms) but did not affect the group difference in the GCC. For the RACR, the between-group difference vanished (P=.968) after linear interpolation but was relatively unaffected by using rotationally linear interpolation (P=.00001). FA histogram analysis and computer simulations confirmed these findings. This work suggests that caution should be exercised in voxel-based group comparisons as spatial normalization may affect the FA value in nonnegligible degrees, particularly in brain areas with predominantly crossing fibers. © 2009 Elsevier Inc. All rights reserved.
Other Subjects
adolescent; algorithm; anisotropy; article; attention deficit disorder; brain region; child; clinical article; computer simulation; controlled study; corpus callosum; diffusion tensor imaging; fractional anisotropy; histogram; human; linear system; male; priority journal; right anterior corona radiata; school child; Adolescent; Adult; Algorithms; Anisotropy; Artifacts; Attention Deficit Disorder with Hyperactivity; Brain; Child; Diffusion Magnetic Resonance Imaging; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Male; Reproducibility of Results; Sensitivity and Specificity; Radiata
Type
journal article

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