https://scholars.lib.ntu.edu.tw/handle/123456789/350636
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang, C.-H. | en_US |
dc.contributor.author | Ku, C.-Y. | en_US |
dc.contributor.author | TONG-RONG JAN | en_US |
dc.creator | Huang, C.-H.;Ku, C.-Y.;Jan, T.-R. | - |
dc.date.accessioned | 2018-09-10T07:37:43Z | - |
dc.date.available | 2018-09-10T07:37:43Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-70449441241&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/350636 | - |
dc.description.abstract | Diosgenin, the major sapogenin contained in the Chinese yam, has recently been shown to promote systemic T helper 1-type immunity in a murine model of airway hypersensitivity. In this study, we hypothesized that diosgenin might be effective in modulating food allergy. BALB/c mice were either left untreated (na?ve; NA) or administered daily with vehicle (VH; olive oil) and/or diosgenin (100 or 200mg/kg) by gavage throughout the experiment. Except for the NA group, the mice were sensitized with ovalbumin (OVA) and repeatedly challenged with intragastric OVA to induce intestinal allergic responses. Diosgenin demonstrated a suppressive effect on the intestinal inflammation, including the occurrence of diarrhea, the infiltration and degranulation of mast cells, and the presence of mucin-containing goblet cells in the duodenum. A protective effect by diosgenin on reducing the crypt depth of the intestine was also observed in OVA-sensitized and challenged mice. Furthermore, the serum production of OVA-specific IgE, and the total IgE was suppressed. In contrast, OVA-specific IgG2a was enhanced by diosgenin treatment in OVA-sensitized mice. These results demonstrated the in vivo anti-allergic activity of diosgenin, which is associated with the suppression of IgE production and mast cell infiltration and degranulation. ? Georg Thieme Verlag KG Stuttgart. | - |
dc.language | en | en |
dc.relation.ispartof | Planta Medica | en_US |
dc.source | AH-Scopus to ORCID | - |
dc.subject | Diosgenin; Food allergy; IgE; Mast cells; Ovalbumin | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | diosgenin; food allergen; immunoglobulin E; immunoglobulin G2a; ovalbumin; allergic reaction; animal experiment; animal model; article; Bagg albino mouse; cell infiltration; controlled study; degranulation; diarrhea; enteritis; feeding; food allergy; goblet cell; immunoglobulin production; immunomodulation; in vivo study; male; mast cell; mouse; nonhuman; Allergens; Animals; Diosgenin; Disease Models, Animal; Food Hypersensitivity; Immunoglobulin E; Male; Mice; Mice, Inbred BALB C; Dioscorea polystachya; Murinae; Mus | - |
dc.title | Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1055/s-0029-1185578 | - |
dc.relation.pages | 1300-1305 | - |
dc.relation.journalvolume | 75 | - |
dc.relation.journalissue | 12 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.orcid | 0000-0003-2771-8381 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 獸醫學系 |
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