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  4. Rosiglitazone reduces cell invasiveness by inducing MKP-1 in human U87MG glioma cells
 
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Rosiglitazone reduces cell invasiveness by inducing MKP-1 in human U87MG glioma cells

Journal
Cancer Letters
Journal Volume
277
Journal Issue
2
Pages
141-148
Date Issued
2009
Author(s)
Jan, H.-J.
Lee, C.-C.
Lin, Y.-M.
Lai, J.-H.
HEN-WEI WEI  
Lee, H.-M.
DOI
10.1016/j.canlet.2008.11.033
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-62849099510&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/350706
Abstract
We sought to investigate the molecular mechanisms by which rosiglitazone (RGZ) inhibits cell invasion in human glioma cells. In this study, we found that RGZ attenuated MMP-2 protein levels, MMP-2 gelatinolytic activity, and cell invasiveness through a PPAR-γ independent pathway. RGZ increased mitogen activated protein kinase phosphatase-1 (MKP-1) expression. The addition of triptolide (a diterpenoid triepoxide, which blocked MKP-1 induction) abolished the inhibitory effects by RGZ. Furthermore, we demonstrated that the knock down of MKP-1 by MKP-1 specific small interference RNA reversed the reduction of MMP-2 secretion, and of cell invasiveness by RGZ. In contrast, the stable expression of MKP-1 in glioma cell lines decreased MMP-2 activity and cell invasiveness. These results suggest that RGZ may mediate the inhibitory effects through MKP-1 induction. Thus, MKP-1 could be a potential target in glioma therapy. ? 2008 Elsevier Ireland Ltd. All rights reserved.
Subjects
Glioma; Matrix metalloproteinase; Mitogen activated protein kinase phosphatase-1
SDGs

[SDGs]SDG3

Other Subjects
gelatinase A; mitogen activated protein kinase phosphatase 1; peroxisome proliferator activated receptor gamma; rosiglitazone; small interfering RNA; triptolide; article; cancer invasion; cell invasion; controlled study; drug inhibition; enzyme activity; enzyme release; glioma; human; human cell; priority journal; protein expression; signal transduction; Cell Line, Tumor; Dual Specificity Phosphatase 1; Glioma; Humans; Matrix Metalloproteinase 2; Neoplasm Invasiveness; PPAR gamma; Signal Transduction; Thiazolidinediones
Type
journal article

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