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  1. NTU Scholars
  2. 生物資源暨農學院
  3. 動物科學技術學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/355553
Title: N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: mechanisms and implications for obesity prevention
Authors: Tai, C.C.
Ding, S.T.
SHIH-TORNG DING 
Keywords: Docosahexaenoic acid; Inflammation; Interleukin-6; N-3 PUFA; Obesity; Serum amyloid A; Tumor necrosis factor-α
Issue Date: 2010
Journal Volume: 21
Journal Issue: 5
Start page/Pages: 357-363
Source: Journal of Nutritional Biochemistry 
Abstract: 
Obesity is a growing problem that threatens the health and welfare of a large proportion of the human population. The n-3 polyunsaturated fatty acids (PUFA) are dietary factors that have potential to facilitate reduction in body fat deposition and improve obesity-induced metabolic syndromes. The n-3 PUFA up-regulate several inflammation molecules including serum amyloid A (SAA), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in hepatocytes and adipocytes. Actions of these inflammation mediators resemble those of n-3 PUFA in the modulation of many lipid metabolism-related genes. For instance, they both suppress expressions of perilipin, sterol regulatory element binding protein-1 (SREBP-1) and lipoprotein lipase (LPL) to induce lipolysis and reduce lipogenesis. This review will connect these direct or indirect regulating pathways between n-3 PUFA, inflammation mediators, lipid metabolism-related genes and body fat reduction. A thorough knowledge of these regulatory mechanisms will lead us to better utilization of n-3 PUFA to reduce lipid deposition in the liver and other tissues, therefore presenting an opportunity for developing new strategies to treat obesity. ? 2010 Elsevier Inc.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-77951498306&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/355553
DOI: 10.1016/j.jnutbio.2009.09.010
SDG/Keyword: adiponectin; docosahexaenoic acid; interleukin 6; lipoprotein lipase; omega 3 fatty acid; peroxisome proliferator activated receptor; saturated fatty acid; serum amyloid A; toll like receptor; tumor necrosis factor alpha; adipocyte; bioaccumulation; body fat distribution; cell differentiation; cytokine production; diet supplementation; enzyme regulation; gene expression regulation; human; inflammation; lipid metabolism; lipogenesis; lipolysis; mediator release; metabolic regulation; nonhuman; obesity; protein expression; protein function; regulatory mechanism; review; upregulation; Adipose Tissue; Animals; Dietary Fats, Unsaturated; Fatty Acids, Omega-3; Humans; Inflammation Mediators; Lipid Metabolism; Liver; Obesity
[SDGs]SDG3
Appears in Collections:動物科學技術學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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