https://scholars.lib.ntu.edu.tw/handle/123456789/355553
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tai, C.C. | en_US |
dc.contributor.author | SHIH-TORNG DING | en_US |
dc.creator | Tai, C.C.;Ding, S.T. | - |
dc.date.accessioned | 2018-09-10T08:07:13Z | - |
dc.date.available | 2018-09-10T08:07:13Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-77951498306&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/355553 | - |
dc.description.abstract | Obesity is a growing problem that threatens the health and welfare of a large proportion of the human population. The n-3 polyunsaturated fatty acids (PUFA) are dietary factors that have potential to facilitate reduction in body fat deposition and improve obesity-induced metabolic syndromes. The n-3 PUFA up-regulate several inflammation molecules including serum amyloid A (SAA), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in hepatocytes and adipocytes. Actions of these inflammation mediators resemble those of n-3 PUFA in the modulation of many lipid metabolism-related genes. For instance, they both suppress expressions of perilipin, sterol regulatory element binding protein-1 (SREBP-1) and lipoprotein lipase (LPL) to induce lipolysis and reduce lipogenesis. This review will connect these direct or indirect regulating pathways between n-3 PUFA, inflammation mediators, lipid metabolism-related genes and body fat reduction. A thorough knowledge of these regulatory mechanisms will lead us to better utilization of n-3 PUFA to reduce lipid deposition in the liver and other tissues, therefore presenting an opportunity for developing new strategies to treat obesity. ? 2010 Elsevier Inc. | - |
dc.language | en | en |
dc.relation.ispartof | Journal of Nutritional Biochemistry | en_US |
dc.source | AH | - |
dc.subject | Docosahexaenoic acid; Inflammation; Interleukin-6; N-3 PUFA; Obesity; Serum amyloid A; Tumor necrosis factor-α | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adiponectin; docosahexaenoic acid; interleukin 6; lipoprotein lipase; omega 3 fatty acid; peroxisome proliferator activated receptor; saturated fatty acid; serum amyloid A; toll like receptor; tumor necrosis factor alpha; adipocyte; bioaccumulation; body fat distribution; cell differentiation; cytokine production; diet supplementation; enzyme regulation; gene expression regulation; human; inflammation; lipid metabolism; lipogenesis; lipolysis; mediator release; metabolic regulation; nonhuman; obesity; protein expression; protein function; regulatory mechanism; review; upregulation; Adipose Tissue; Animals; Dietary Fats, Unsaturated; Fatty Acids, Omega-3; Humans; Inflammation Mediators; Lipid Metabolism; Liver; Obesity | - |
dc.title | N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: mechanisms and implications for obesity prevention | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jnutbio.2009.09.010 | - |
dc.identifier.scopus | 2-s2.0-77951498306 | - |
dc.identifier.isi | WOS:000277054500001 | - |
dc.relation.pages | 357-363 | - |
dc.relation.journalvolume | 21 | - |
dc.relation.journalissue | 5 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Office of the Vice President | - |
crisitem.author.orcid | 0000-0002-9866-1776 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | Administrative Unit | - |
顯示於: | 動物科學技術學系 |
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