https://scholars.lib.ntu.edu.tw/handle/123456789/355570
標題: | Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials | 作者: | TZU-MING PAN | 關鍵字: | Antioxidase activity; Ethanol extract of red mold dioscorea (RMDE); Hamster buccal pouch (HBP); Inflammatory cytokines; Oral cancer | 公開日期: | 2010 | 卷: | 58 | 期: | 11 | 起(迄)頁: | 6715-6720 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | Monascus-fermented products offer valuable therapeutic benefits and have been extensively used in East Asia. This study investigated the prevention of oral tumor formation and antioxidative ability of the ethanol extracts from red mold dioscorea (RMDE) on 7,12-dimethyl-1,2-benz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. The HBP was painted with DMBA three times per week for 14 weeks, and animals were painted with celecoxib, RMDE (50, 100, and 200 mg/kg of bw), and ethanol extracts from dioscorea (200 mg/kg of bw) on days alternate to the DMBA application. The results demonstrated that RMDE attenuated tumor formation by elevating the antioxidase activity and suppressing the overproduction of reactive oxygen species, nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in the HBP caused by DMBA induction. These results indicated that RMDE exerted anti-inflammatory and antioxidative activity to prevent oral cancer. Therefore, the metabolite from Monascus fermentation may serve as a possible functional edible substance for the prevention of oral cancer. ? 2010 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-77953156481&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/355570 |
DOI: | 10.1021/jf100889w | SDG/關鍵字: | 7,12 dimethylbenz[a]anthracene; antiinflammatory agent; antioxidant; carcinogen; plant extract; animal; article; disease model; drug effect; fermentation; hamster; human; immunology; injury; male; metabolism; microbiology; Monascus; mouth; mouth tumor; Syrian hamster; yam; 9,10-Dimethyl-1,2-benzanthracene; Animals; Anti-Inflammatory Agents; Antioxidants; Carcinogens; Cricetinae; Dioscorea; Disease Models, Animal; Fermentation; Humans; Male; Mesocricetus; Monascus; Mouth; Mouth Neoplasms; Plant Extracts; Animalia; Cricetinae; Dioscorea; Dioscorea alata; Monascus |
顯示於: | 生化科技學系 |
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