Anti-diabetic effects of monascus purpureus NTU 568 fermented products on streptozotocin-induced diabetic rats
Journal
Journal of Agricultural and Food Chemistry
Journal Volume
58
Journal Issue
13
Pages
7634-7640
Date Issued
2010
Author(s)
Abstract
Red-mold-fermented products have the unique ability to economically produce many secondary metabolites and are known to improve blood circulation. Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. In the current study, we examine the effect of Monascus purpureus NTU 568 fermented products on fasting blood glucose and oral glucose tolerance testing (OGTT) in streptozotocin-induced diabetic rats. After 8 weeks of being fed with red-mold-fermented products at a dose of 200 mg/kg, the experimental results indicate that oral administration of red-mold-fermented products can delay the development of the plasma glucose level in rats. A significant reduction was found in urine sugar and urine protein levels. The study scientifically validates the widely claimed use of red-mold-fermented products as an ethnomedicine to treat diabetes mellitus. ? 2010 American Chemical Society.
Subjects
Anti-diabetic; Diabetes; Insulin resistance; Monascus purpureus ntu 568; Streptozotocin
SDGs
Other Subjects
antidiabetic agent; streptozocin; antidiabetic agent; glucose blood level; animal; article; chemically induced disorder; Coix; diabetes mellitus; disease model; drug effect; fermentation; glucose blood level; human; male; metabolism; microbiology; Monascus; randomization; rat; sweet potato; Wistar rat; chemically induced; diabetes mellitus; drug effects; Monascus; Animals; Blood Glucose; Coix; Diabetes Mellitus; Disease Models, Animal; Fermentation; Humans; Hypoglycemic Agents; Ipomoea batatas; Male; Monascus; Random Allocation; Rats; Rats, Wistar; Streptozocin; Monascus; Monascus purpureus; Rattus; Animals; Blood Glucose; Coix; Diabetes Mellitus; Disease Models, Animal; Fermentation; Humans; Hypoglycemic Agents; Ipomoea batatas; Male; Monascus; Random Allocation; Rats; Rats, Wistar; Streptozocin
Type
journal article