Angelman Syndrome: Finding the Lost Arc
Journal
Cell
Journal Volume
140
Journal Issue
5
Pages
608-610
Date Issued
2010
Author(s)
HWAN-CHING TAI
Schuman, E.M.
Abstract
Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A substrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight into synaptic defects that may underlie the cognitive deficits in Angelman syndrome.
SDGs
Type
journal article