https://scholars.lib.ntu.edu.tw/handle/123456789/356387
Title: | Intracellular pH-responsive mesoporous silica nanoparticles for the controlled release of anticancer chemotherapeutics | Authors: | Lee, C.-H. Cheng, S.-H. Huang, I.-P. Souris, J.S. Yang, C.-S. CHUNG-YUAN MOU Lo, L.-W. |
Keywords: | Antitumor agents; Apoptosis; Controlled release; Doxorubicin; Mesoporous silica | Issue Date: | 2010 | Journal Volume: | 49 | Journal Issue: | 44 | Start page/Pages: | 8214-8219 | Source: | Angewandte Chemie - International Edition | Abstract: | Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death. ? 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-78249241778&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/356387 |
DOI: | 10.1002/anie.201002639 | SDG/Keyword: | Anti-tumor agents; Apoptosis; Controlled release; Doxorubicin; Mesoporous Silica; Cell death; Mesoporous materials; Nanoparticles; Silica; antineoplastic agent; drug carrier; nanoparticle; silicon dioxide; article; cell line; chemistry; confocal microscopy; human; infrared spectroscopy; pH; spectrofluorometry; transmission electron microscopy; Antineoplastic Agents; Cell Line; Drug Carriers; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles; Silicon Dioxide; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared |
Appears in Collections: | 化學系 |
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