https://scholars.lib.ntu.edu.tw/handle/123456789/356862
標題: | Steroid and cembranoids from the Dongsha atoll soft coral Lobophytum sarcophytoides | 作者: | Lu, Y. Lin, Y.-C. Wen, Z.-H. Su, J.-H. Sung, P.-J. Hsu, C.-H. Kuo, Y.-H. Chiang, M.Y. CHANG-FENG DAI Sheu, J.-H. |
關鍵字: | HBXZGJYKFRYIFQ-NBGGPTHLSA-N; IRLJYXHINXXWKC-GHZBUWTKSA-N; KBQKZBYGDQCBTJ-YQGAQXSRSA-N; OKPPSLJDJGOWAJ-UWVYSTBFSA-N; YQXSXPBPDWRFHK- LXIPXPQRSA-N | 公開日期: | 2010 | 卷: | 66 | 期: | 35 | 起(迄)頁: | 7129-7135 | 來源出版物: | Tetrahedron | 摘要: | A novel sterol, sarcophytosterol (1), and four new cembranoids, sarcophytolins A-D (2-5), have been isolated from the soft coral Lobophytum sarcophytoides along with four known metabolites 6-9. The relative structures of new metabolites were elucidated on the basis of extensive spectroscopic analyses and X-ray diffraction analysis of 1, and the absolute configurations of 1 and 5 were determined by Mosher's method and CD spectrum, respectively. Compound 1 is a steroid possessing an unusual (20R,23R,24R)-23,24-dimethyl-20- hydroxy side chain. Compounds 3, 6, 8, and 9 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines. Furthermore, while 1 could effectively enhance the expression of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells, compounds 2, 3, 5-7 and 9 were found to effectively inhibit the accumulation of the pro-inflammatory of iNOS. ? 2010 Elsevier Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-77955420236&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/356862 |
DOI: | 10.1016/j.tet.2010.06.094 | SDG/關鍵字: | antiinflammatory agent; antineoplastic agent; cembranoid; cyclooxygenase 2; inducible nitric oxide synthase; lipopolysaccharide; sarcophytolin A; sarcophytolin B; sarcophytolin C; sarcophytolin D; sarcophytosterol; steroid; unclassified drug; antiinflammatory activity; antineoplastic activity; article; cancer cell culture; carbon nuclear magnetic resonance; circular dichroism; coral; crystal structure; cytotoxicity; drug isolation; drug mechanism; drug structure; human; human cell; Lobophytum sarcophytoides; macrophage; nuclear Overhauser effect; priority journal; protein expression; proton nuclear magnetic resonance; stereochemistry; X ray diffraction; Alcyonacea; Lobophytum |
顯示於: | 海洋研究所 |
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