https://scholars.lib.ntu.edu.tw/handle/123456789/362172
標題: | Antiosteoporotic effects of lactobacillus-fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice | 作者: | Chiang, Shen-Shih TZU-MING PAN Pan, Tzu-Ming |
關鍵字: | Lactobacillus-fermented soy skim milk; Osteoporosis; ovariectomized mice; trabecular bone | 公開日期: | 2011 | 卷: | 59 | 期: | 14 | 起(迄)頁: | 7734-7742 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | Osteoporosis is a major skeletal disease associated with loss of estrogen in postmenopausal women. In this study, Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101F) and Lactobacillus plantarum NTU 102 (NTU 102F) were used as starters to ferment soy skim milk. This was then used as a nutritional supplement for 8 weeks to ovariectomized (OVX) mice. This study reveals that soy skim milk fermented with lactobacilli can increase the contents of aglycone isoflavones, soluble calcium, and vitamin D 3. The trabecular bone volumes and trabecular number of the distal femur in mice fed NTU 101F increased by a factor of 1.48 and 1.74 compared with the OVX group. The bone network density and thickness of the distal metaphyseal trabecular in mice fed NTU 101F and Fosamax was significantly greater than that of OVX mice. These results suggest that fermented soy skim milk can attenuate bone loss in OVX mice and lower the risk of osteoporosis. ? 2011 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-79960594662&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/362172 |
DOI: | 10.1021/jf2013716 | SDG/關鍵字: | Aglycones; Bone loss; Bone mineral density; Distal femurs; Isoflavones; Lactobacillus plantarum; Network density; Nutritional supplements; Osteoporosis; ovariectomized mice; Postmenopausal women; Skeletal disease; Skim milks; Trabecular bones; Vitamin-D; Bacilli; Bone; Mammals; Fermented milk; animal; bone density; C57BL mouse; chemistry; conference paper; diet therapy; disease model; drug effect; female; femur; fermentation; human; Lactobacillus; metabolism; microbiology; mouse; ovariectomy; pathophysiology; postmenopause osteoporosis; soybean; soybean milk; Animals; Bone Density; Disease Models, Animal; Female; Femur; Fermentation; Humans; Lactobacillus; Mice; Mice, Inbred C57BL; Osteoporosis, Postmenopausal; Ovariectomy; Soy Foods; Soy Milk; Lactobacillus; Lactobacillus paracasei subsp. paracasei; Lactobacillus plantarum; Mus |
顯示於: | 生化科技學系 |
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