https://scholars.lib.ntu.edu.tw/handle/123456789/362207
標題: | Effect of heat-inactivated kefir-isolated lactobacillus kefiranofaciens M1 on preventing an allergic airway response in mice | 作者: | Hong, W.-S. Chen, Y.-P. Dai, T.-Y. Huang, I.-N. MING-JU CHEN |
關鍵字: | Allergy; asthma; kefir; Lactobacillus kefiranofaciens; Th17 | 公開日期: | 2011 | 卷: | 59 | 期: | 16 | 起(迄)頁: | 9022-9031 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | In this study, we assessed the anti-asthmatic effects of heat-inactivated Lactobacillus kefiranofaciens M1 (HI-M1) and its fermented milk using different feeding procedures and at various dosage levels. The possible mechanisms whereby HI-M1 has anti-allergic asthmatic effects were also evaluated. Ovalbumin (OVA)-allergic asthma mice that have been orally administrated the HI-M1 samples showed strong inhibition of production of T helper cell (Th) 2 cytokines, pro-inflammatory cytokines, and Th17 cytokines in splenocytes and bronchoalveolar fluid compared to control mice. An increase in regulatory T cell population in splenocytes in the allergic asthma mice after oral administration of H1-M1 was also observed. In addition, all of the features of the asthmatic phenotype, including specific IgE production, airway inflammation, and development of airway hyperresponsiveness, were depressed in a dose-dependent manner by treatment. These findings support the possibility that oral feeding of H1-M1 may be an effective way of alleviating asthmatic symptoms in humans. ? 2011 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-80051722680&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/362207 |
DOI: | 10.1021/jf201913x | SDG/關鍵字: | Airway inflammation; Allergic asthma; asthma; Cytokines; Dosage levels; Dose-dependent manner; kefir; Lactobacillus kefiranofaciens; Oral administration; Ovalbumins; Splenocytes; T cells; Th17; Cell culture; Cell proliferation; Diseases; Fermented milk; Mammals; allergen; animal; asthma; Bagg albino mouse; dairy product; female; heat; immunology; Lactobacillus; microbiology; mouse; review; Allergens; Animals; Asthma; Cultured Milk Products; Female; Hot Temperature; Lactobacillus; Mice; Mice, Inbred BALB C; Lactobacillus kefiranofaciens; Mus |
顯示於: | 動物科學技術學系 |
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