https://scholars.lib.ntu.edu.tw/handle/123456789/362294
標題: | Overexpression of α-enolase correlates with poor survival in canine mammary carcinoma | 作者: | Chu, P.-Y. Hsu, N.C. TAI-CHING LIAO Shih, N.-Y. Hou, M.-F. CHEN-HSUAN LIU |
公開日期: | 2011 | 卷: | 7 | 來源出版物: | BMC Veterinary Research | 摘要: | Background: α-Enolase (ENO1) is a key glycolytic enzyme implicated in the development of many human cancers including breast cancer. Increased expression of ENO1 has recently been reported in estrogen (ER)-positive human breast cancer patients. The present study examined the expression of ENO1 and assessed its significance in canine mammary carcinoma.Results: Immunohistochemical staining was employed to investigate the expression of ENO1 in 82 cases of canine mammary tumor (32 benign tumors and 50 carcinomas). Quantification of immunohistochemistry was carried out using Quick score and the results showed cytoplasmic ENO1 overexpression in 9 of the 50 carcinomas (18%). Overexpression of ENO1 correlated significantly with shorter cause-specific survival (P = 0.019), but was not associated with ER positivity in canine mammary carcinoma.Conclusions: Our findings suggest that overexpression of ENO1 may be used as a prognostic marker for poor outcome in canine mammary carcinoma. ? 2011 Chu et al; licensee BioMed Central Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-80054757041&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/362294 |
DOI: | 10.1186/1746-6148-7-62 | SDG/關鍵字: | biological marker; enolase; animal; animal disease; article; chemistry; dog; dog disease; experimental neoplasm; female; gene expression regulation; immunoblotting; metabolism; mortality; udder; Animals; Biological Markers; Dog Diseases; Dogs; Female; Gene Expression Regulation, Neoplastic; Immunoblotting; Mammary Glands, Animal; Mammary Neoplasms, Animal; Phosphopyruvate Hydratase |
顯示於: | 獸醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。