https://scholars.lib.ntu.edu.tw/handle/123456789/362295
標題: | Elevated Kruppel-like factor 4 transcription factor in canine mammary carcinoma | 作者: | Chu, P.-Y. Hsu, N.C-H. TAI-CHING LIAO Yeh, K.-T. Hou, M.-F. CHEN-HSUAN LIU |
公開日期: | 2011 | 來源出版物: | BMC Veterinary Research | 摘要: | Kr?ppel-like factors (KLFs) are critical regulators of biological and physiological systems and have been extensively studied for their roles in cell proliferation, differentiation and survival in the context of cancer. Among the KLFs, KLF4 is highly expressed in human breast cancers and plays an oncogenic role. The present study examined the expression of KLF4 and assessed its significance in canine mammary carcinoma. Immunohistochemistry was employed to investigate the expression of KLF4 in 142 cases of canine mammary tumor. 75 of the 142 (52.8%) cases were histologically confirmed as mammary carcinoma. Quantification of immunohistochemistry was carried out using Quick score which multiply the staining intensity by the percentage of positive cells. High KLF4 expression was identified in 44 of the 75 (59%) dogs with mammary carcinoma and none in the benign cases. High KLF4 expression occurred only in the tumor cells and not the adjacent normal cells in mammary carcinoma (P < 0.001). Moreover, the high expression level of KLF4 expression was statistically associated with poor grade, late stage, histological subtypes of simple and complex carcinoma, and shorter 24-month survival. The Kaplan-Meier survival analysis also indicated that dogs with high nuclear KLF4 expression had a significantly shorter survival than those with low/moderate KLF4 expression (P = 0.011). KLF4 is highly and frequently expressed in canine mammary carcinoma and correlates with a more aggressive phenotype. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-80053519255&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/362295 |
DOI: | 10.1186/1746-6148-7-58 | SDG/關鍵字: | kruppel like factor; kruppel like factor 4; animal; animal disease; article; carcinoma; dog; dog disease; experimental neoplasm; female; gene expression regulation; metabolism; pathology; phenotype; udder; Animals; Carcinoma; Dog Diseases; Dogs; Female; Gene Expression Regulation, Neoplastic; Kruppel-Like Transcription Factors; Mammary Glands, Animal; Mammary Neoplasms, Animal; Phenotype |
顯示於: | 獸醫學系 |
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