Polyoxygenated sterols from freshwater clam
Journal
Helvetica Chimica Acta
Journal Volume
94
Journal Issue
5
Pages
892-896
Date Issued
2011
Author(s)
Abstract
Abstract Two new biologically active polyoxygenated sterols, 3,5,9‐trihydroxycholest‐7‐en‐6‐one ( 1 ) and cholest‐7‐ene‐3,6,9‐triol ( 3 ), together with one known sterone, topsentisterol D3 ( 2 ), were isolated from freshwater clam ( Corbicula fluminea Muller ; an important cultured edible shellfish in Taiwan). The structure elucidation of sterols 1 – 3 were accomplished by 1 H‐ and 13 C‐NMR, HMQC, and HMBC, and MS analyses. The sterols 1 – 3 displayed cytotoxicities against the human hepatoma Hep G2 cells ( IC 50 : 6.04±0.07, 40.78±4.28, and 10.57±0.51 μg/ml, resp.).
SDGs
Type
journal article