https://scholars.lib.ntu.edu.tw/handle/123456789/362918
Title: | Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate | Authors: | Pan, M.-H. Chiou, Y.-S. Wang, Y.-J. Ho, C.-T. Lin, J.-K. MIN-HSIUNG PAN |
Issue Date: | 2011 | Journal Volume: | 2 | Journal Issue: | 2 | Start page/Pages: | 101-110 | Source: | Food and Function | Abstract: | The consumption of green tea has long been associated with a reduced risk of cancer development. (-)-Epicatechin-3-gallate (ECG) or (-)-epigallocatechin- 3-gallate (EGCG) are the major antioxidative polyphenolic compounds of green tea. They have been shown to exert growth-inhibitory potential of various cancer cells in culture and antitumor activity in vivo models. ECG or EGCG could interact with various molecules like proteins, transcription factors, and enzymes, which block multiple stages of carcinogenesis via regulating intracellular signaling transduction pathways. Moreover, ECG and EGCG possess pharmacological and physiological properties including induction of phase II enzymes, mediation of anti-inflammation response, regulation of cell proliferation and apoptosis effects and prevention of tumor angiogenesis, invasion and metastasis. Numerous review articles have been focused on EGCG, however none have been focused on ECG despite many studies supporting the cancer preventive potential of ECG. To develop ECG as an anticarcinogenic agent, more clear understanding of the cell signaling pathways and the molecular targets responsible for chemopreventive and chemotherapeutic effects are needed. This review summarizes recent research on the ECG-induced cellular signal transduction events which implicate in cancer management. ? 2011 The Royal Society of Chemistry. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-79951659522&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/362918 |
DOI: | 10.1039/c0fo00174k | SDG/Keyword: | Anti-inflammation; Anti-tumor activities; Anticarcinogenic agents; Cancer cells; Cancer chemoprevention; Cancer development; Cancer management; Cell signaling; Cellular signal transduction; Chemopreventive; Epicatechin; Epigallocatechin-3-gallate; Gallate; Green tea; In-vivo; Intracellular signaling; Molecular targets; Multistage carcinogenesis; Phase II; Physiological properties; Polyphenolic compound; Proliferation and apoptosis; Tumor angiogenesis; Bacteriophages; Catalysts; Cell culture; Cell death; Cell proliferation; Diseases; Drug products; Electrochromic devices; Enzymes; Molecular physics; Pathology; Physiological models; Signal transduction; Signaling; Transcription factors; Electrocardiography; antineoplastic agent; catechin; drug derivative; epicatechin gallate; epigallocatechin gallate; chemistry; drug effect; human; metabolism; neoplasm; physiology; review; signal transduction; tea; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Catechin; Humans; Neoplasms; Signal Transduction; Tea |
Appears in Collections: | 食品科技研究所 |
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