https://scholars.lib.ntu.edu.tw/handle/123456789/363592
標題: | Bioactive eunicellin-based diterpenoids from the soft coral Cladiella krempfi | 作者: | Tai, C.-J. Su, J.-H. Huang, M.-S. Wen, Z.-H. CHANG-FENG DAI Sheu, J.-H. |
關鍵字: | Anti-inflammatory activity; Cladiella krempfi; Cytotoxic activity; Eunicellin-based diterpenoids; Krempfielins; Soft coral | 公開日期: | 2011 | 卷: | 9 | 期: | 10 | 起(迄)頁: | 2036-2045 | 來源出版物: | Marine Drugs | 摘要: | Four new eunicellin-based diterpenoids, krempfielins A-D (1-4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. ? 2011 by the authors; licensee MDPI. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-80054915501&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/363592 |
DOI: | 10.3390/md9102036 | SDG/關鍵字: | cyclooxygenase 2; diterpenoid; krempfielin A; krempfielin B; krempfielin C; krempfielin D; lipopolysaccharide; nitric oxide synthase; unclassified drug; antiinflammatory activity; article; cancer cell culture; carbon nuclear magnetic resonance; Cladiella krempfi; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; drug synthesis; human; human cell; in vitro study; macrophage; nonhuman; nuclear Overhauser effect; spectroscopy; Alcyonacea; Cladiella |
顯示於: | 海洋研究所 |
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