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  4. Glutathione S-transferase, incense burning and asthma in children
 
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Glutathione S-transferase, incense burning and asthma in children

Journal
European Respiratory Journal
Journal Volume
37
Journal Issue
6
Pages
1371-1377
Date Issued
2011
Author(s)
Wang, I.-J.
Tsai, C.-H.  
Chen, C.-H.
Tung, K.-Y.
Lee, Y.L.
DOI
10.1183/09031936.00137210
URI
http://www.scopus.com/inward/record.url?eid=2-s2.0-79958008619&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/367320
Abstract
Incense burning is a popular practice in many family homes and temples. However, little is known about the effects of indoor incense burning and genetic polymorphisms on asthma. This study evaluated the effects of indoor incense burning and glutathione S-transferase (GST) genetic polymorphisms on asthma and wheeze. In 2007, 3,764 seventh-grade schoolchildren (mean±SD age 12.42±0.65 yrs) were evaluated using a standard questionnaire for information about respiratory symptoms and environmental exposures. Multiple logistic regressions were performed to assess the association between GST polymorphisms and incense burning frequency on asthma and wheeze, after adjusting for potential confounders. The frequency of incense burning at home was associated with increased risk of current asthma (p=0.05), medication use (p=0.03) and exercise wheeze (p=0.001). GSTθ1 (GSTT1) null genotypes were associated with current asthma (OR 1.43, 95% CI 1.00-2.04) and medication use (OR 1.46, 95% CI 1.01-2.22). GSTT1 showed a significant interactive effect with incense burning on current asthma, current wheeze and nocturnal wheeze. The frequency of incense burning was associated with increased risk of current asthma, medication use, lifetime wheeze, nocturnal wheeze and exercise wheeze in an exposure - response manner among children with GSTT1 null genotype (p<0.05). Incense burning is a risk factor for asthma and wheezing, especially in GSTT1 genetically susceptible children. Copyright?ERS 2011.
Subjects
Asthma; Gene - environment interaction; GSTT1; Incense burning
SDGs

[SDGs]SDG3

Other Subjects
glutathione transferase; article; asthma; child; controlled study; disease association; drug use; environmental exposure; exercise; female; genetic polymorphism; genetic susceptibility; genotype; human; incense; major clinical study; male; priority journal; questionnaire; risk assessment; risk factor; school child; wheezing; Adolescent; Air Pollution, Indoor; Asthma; Ceremonial Behavior; Child; Female; Genetic Predisposition to Disease; Glutathione Transferase; Humans; Male; Polymorphism, Genetic; Questionnaires; Respiratory Sounds; Smoke
Type
journal article

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