https://scholars.lib.ntu.edu.tw/handle/123456789/367381
標題: | Total synthesis of polyprenyl N-Glycolyl Lipid II as a mycobacterial transglycosylase substrate | 作者: | Meng F.-C. Chen K.-T. Huang L.-Y. Shih H.-W. Chang H.-H. Nien F.-Y. PI-HUI LIANG Cheng T.-J. R. Wong C.-H. Cheng W.-C. |
公開日期: | 2011 | 卷: | 13 | 期: | 19 | 起(迄)頁: | 5306-5309 | 來源出版物: | Organic Letters | 摘要: | A feasible synthetic approach toward the Mycobacterium tuberculosis (Mtb) N-glycolyl lipid II-like molecule 1 is described. Compound 1 bears pendant undecaprenol and L-lysin moieties instead of the naturally occurring decaprenol and meso-diaminopimelic acid, which are not readily available. Functionalization of 1 with a fluorophore on the peptide side chain gave 14, which was found to be recognized as an Mtb TGase substrate. This result suggests it has tremendous utility for mechanistic studies, the characterization of mycobacterial enzymes, and mycobacterial TGase inhibitor evaluation. ? 2011 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-80054762741&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/367381 |
DOI: | 10.1021/ol2021687 | SDG/關鍵字: | glycolipid; glycosyltransferase; article; chemistry; enzyme specificity; metabolism; Mycobacterium tuberculosis; Glycolipids; Glycosyltransferases; Mycobacterium tuberculosis; Substrate Specificity |
顯示於: | 藥學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。