https://scholars.lib.ntu.edu.tw/handle/123456789/368360
標題: | Effective treatment of 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch precancerous lesions by topical photosan-mediated photodynamic therapy | 作者: | CHUN-PIN CHIANG Huang, Wan-Ting Lee, Jeng-Woei Hsu, Yih-Chih |
關鍵字: | DMBA; hamster buccal pouch precancer; oral precancerous lesions; photosan; topical photodynamic therapy | 公開日期: | 2012 | 卷: | 34 | 期: | 4 | 起(迄)頁: | 505-512 | 來源出版物: | Head and Neck | 摘要: | Background Previous studies found that topical photodynamic therapy (PDT) is very effective for human oral precancerous lesions. Methods This study evaluated whether topical photosan-mediated PDT (topical photosan-PDT), using a 640-nm light-emitting diode (LED) light, is an effective treatment modality for hamster buccal pouch precancerous lesions. Fourteen 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch precancerous lesions were treated with topical photosan-PDT using the 640-nm LED light twice a week. Results All 14 of the precancerous lesions showed a complete histologically confirmed response to the lesions after an average of 3.79 (range, 3-5) PDT treatments. Normal and precancerous pouch mucosae in the other 4 hamsters received 17 or 19 treatments of topical photosan-PDT showed no cumulative side effects. No recurrence of the lesions was found in these 18 PDT-treated hamsters after a follow-up period of 50 weeks. Conclusion Our findings indicate that topical photosan-PDT is a very effective treatment modality for DMBA-induced hamster buccal pouch precancerous lesions. Copyright ? 2011 Wiley Periodicals, Inc. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84858072859&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/368360 |
DOI: | 10.1002/hed.21761 | SDG/關鍵字: | 7,12 dimethylbenz[a]anthracene; hematoporphyrin derivative; animal experiment; animal model; animal tissue; article; cheek pouch precancer; controlled study; follow up; histopathology; light emitting diode; male; nonhuman; photodynamic therapy; precancer; priority journal; treatment outcome; treatment response; 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Biopsy, Needle; Cheek; Cricetinae; Disease Models, Animal; Hematoporphyrins; Immunohistochemistry; Male; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Random Allocation; Reference Values; Spectrometry, Fluorescence; Treatment Outcome |
顯示於: | 口腔生物科學研究所 |
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