https://scholars.lib.ntu.edu.tw/handle/123456789/368741
標題: | The risk of developing non-melanoma skin cancer, lymphoma and melanoma in patients with psoriasis in Taiwan: A 10-year, population-based cohort study | 作者: | Lee, Meng-Sui Lin, Ruey-Yi Chang, Yun-Ting Lai, Mei-Shu |
公開日期: | 2012 | 卷: | 51 | 期: | 12 | 起(迄)頁: | 1454-1460 | 來源出版物: | International Journal of Dermatology | 摘要: | Background Hospitalized psoriasis patients are known to have a higher risk of malignancy (e.g., nonmelanoma skin cancer [NMSC], lymphoma, and melanoma) than the general population; currently, it is unclear whether this risk is affected by psoriasis severity. The aim of this study was to compare the cancer risk of patients with mild and severe psoriasis and the general population. Methods Data for this retrospective population-based cohort study were obtained from the Taiwan National Health Insurance Research Database. This study included 7061 patients with a first-time diagnosis of psoriasis. All study individuals were followed up until the end of 2007. The crude incidence density ratio and standardized incidence ratio (SIR) of NMSC, melanoma, and lymphoma were determined. Results Among psoriasis patients, the most common cancer was NMSC (density ratio: 7.5); women were at a higher risk of NMSC than men (density ratios: 8.08 vs. 7.0). Psoriasis patients in the south geographic group or in the 50- to 59-year-old age group were most likely to develop NMSC. The NMSC SIR was higher among patients with severe psoriasis than among patients with mild psoriasis (SIR: 3.72 vs. 7.08). The lymphoma and melanoma SIR among patients with severe psoriasis was also high (lymphoma SIR: 4.85; melanoma: 11.01). Conclusions Psoriasis carries an elevated risk of NMSC and lymphoma. This effect is modified by the severity of psoriasis, age, gender, and geographic location. ? 2012 The International Society of Dermatology. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84869808499&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/368741 |
DOI: | 10.1111/j.1365-4632.2011.05310.x | SDG/關鍵字: | adolescent; adult; aged; article; cancer incidence; cancer risk; child; disease severity; female; follow up; human; infant; lymphoma; major clinical study; male; melanoma; non melanoma skin cancer; population; preschool child; psoriasis; retrospective study; school child; sex difference; Taiwan; Adolescent; Adult; Age Distribution; Aged; Child; Child, Preschool; Female; Humans; Incidence; Infant; Infant, Newborn; Lymphoma; Male; Melanoma; Middle Aged; National Health Programs; Psoriasis; Retrospective Studies; Risk Factors; Sex Distribution; Skin Neoplasms; Taiwan; Young Adult |
顯示於: | 流行病學與預防醫學研究所 |
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