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  1. NTU Scholars
  2. 醫學院
  3. 腫瘤醫學研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/369163
Title: Dynamics of circulating endothelial cells and endothelial progenitor cells in breast cancer patients receiving cytotoxic chemotherapy
Authors: Kuo, Yu-Hsuan
Lin, Ching-Hung
Shau, Wen-Yi
Chen, Te-Jung
Yang, Shih-Hung
Huang, Shu-Min
Hsu, Chun
Lu, Yen-Shen
Cheng, Ann-Lii
Issue Date: 2012
Journal Volume: 12
Source: BMC Cancer 
Abstract: 
Background: The abundance of circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPs), which serve as surrogate markers for angiogenesis, may be affected by chemotherapy. We studied their dynamic change during consecutive cycles of chemotherapy.Methods: We collected blood samples from 15 breast cancer patients, who received a total of 56 courses of systemic chemotherapy, and measured the CECs, viable CECs (V-CECs), and CEPs by six-color flow cytometry within the seven days prior to chemotherapy, twice a week during the first and second cycles of chemotherapy, and then once a week during the subsequent cycles.Results: The CEC, V-CEC, and CEP levels all significantly decreased from day 1 of treatment to the first week of chemotherapy. After one week of chemotherapy, the CEC and V-CEC levels returned to a level similar to day 1. The CEP level remained significantly reduced after the first week of chemotherapy, but gradually rebounded until the next course of chemotherapy. After six cycles of chemotherapy, the total number of CEC and V-CEC cells trended toward a decrease and the CEP cells toward an increase. Clinical factors, including the existence of a tumor, chemotherapy regimens, and the use of granulocyte colony stimulating factor, did not significantly affect these results.Conclusions: The CEC and CEP counts change dynamically during each course of chemotherapy and after the chemotherapy cycles, providing background data for any future study planning to use CECs and CEPs as surrogate markers of angiogenesis in antiangiogenesis treatments combined with chemotherapy. ? 2012 Kuo et al.; licensee BioMed Central Ltd.
URI: http://www.scopus.com/inward/record.url?eid=2-s2.0-84871526730&partnerID=MN8TOARS
http://scholars.lib.ntu.edu.tw/handle/123456789/369163
DOI: 10.1186/1471-2407-12-620
metadata.dc.subject.other: carboplatin; cyclophosphamide; docetaxel; doxorubicin; epirubicin; fluorouracil; folinic acid; granulocyte colony stimulating factor; navelbine; paclitaxel; trastuzumab; adjuvant therapy; adult; aged; article; breast cancer; cancer chemotherapy; cell activity; cell count; circulating endothelial cell; circulating endothelial progenitor cell; clinical article; continuous infusion; endothelial progenitor cell; endothelium cell; female; human; human cell; multiple cycle treatment; treatment duration; treatment response; viable circulating endothelial cell; Adult; Aged; Antineoplastic Agents; Biological Markers; Breast Neoplasms; Endothelial Cells; Female; Humans; Middle Aged; Neoplastic Cells, Circulating; Neovascularization, Pathologic; Stem Cells
[SDGs]SDG3
Appears in Collections:腫瘤醫學研究所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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