DC 欄位 | 值 | 語言 |
dc.contributor | 臺大醫院-小兒部;臺大醫院-內科部; | en |
dc.contributor.author | JIA-FENG WU | en_US |
dc.contributor.author | CHIEN-HUNG CHEN | en_US |
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.contributor.author | Lin, Ying-Ting | en_US |
dc.contributor.author | HUEY-LING CHEN | en_US |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.creator | Wu, Jia-Feng;Chen, Chien-Hung;Ni, Yen-Hsuan;Lin, Ying-Ting;Chen, Huey-Ling;Hsu, Hong-Yuan;Chang, Mei-Hwei | en |
dc.creator | Wu, J.-F. and Chen, C.-H. and Ni, Y.-H. and Lin, Y.-T. and Chen, H.-L. and Hsu, H.-Y. and Chang, M.-H. | - |
dc.creator | 倪衍玄 ;張美惠 ;許宏遠 ;林于粲 ;吳嘉峰 ;陳健弘 ;陳慧玲 | zh-tw |
dc.date.accessioned | 2018-09-10T09:16:20Z | - |
dc.date.available | 2018-09-10T09:16:20Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84864955687&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/369355 | - |
dc.description.abstract | Background.We sought to elucidate the impacts of the Toll-like receptors (TLRs) on spontaneous hepatitis B virus (HBV) e antigen (HBeAg) and hepatitis B s antigen (HBsAg) seroconversion in chronic HBV-infected patients.Methods.Human TLR2, TLR4, TLR5, and TLR9 gene polymorphisms were assessed in 278 HBeAg-positive, chronic HBV-infected patients. Additionally, HBV core antigen (HBcAg) in vitro stimulation using peripheral blood mononuclear cells (PBMCs) from 113 patients was done to assess interferon (IFN-) production.Results.Of the study subjects, 204 (73.4) developed spontaneous HBeAg seroconversion, 21 (7.6) developed spontaneous HBsAg clearance, and 10 (3.6) had spontaneous HBsAg seroconversion during the 19.1 ± 9.9 years of follow-up. The T allele at TLR5 rs5744174 (p.Phe616Leu) and the C allele at TLR9 rs5743836 promoter predicted earlier HBeAg seroconversion (hazard ratios [HRs], 2.45 and 3.65; P =. 04, and. 006, respectively). The TLR5 rs5744174 T allele carriers have higher PBMCs IFN-secretion to HBcAg stimulation (P=. 0002). The G allele carriers at TLR4 rs4986790 (p.Asp299Gly) predicted spontaneous HBsAg seroclearance (HR, 18.73; P <. 001) and seroconversion (HR, 43.45; P <. 001).Conclusions. Toll-like receptor 5 rs5744174 (p.Phe616Leu) and TLR9 rs5743836 promoter area polymorphism were associated with earlier spontaneous HBeAg seroconversion. Toll-like receptor 4 rs4986790 (p.Asp299Gly) was associated with HBsAg seroclearance/seroconversion in chronic HBV patients. Toll-like receptor 5 rs5744174 (p.Phe616Leu) was associated with higher IFN-production in chronic HBV-infected patients. ? The Author 2012. | en_US |
dc.format.extent | 103 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en | en |
dc.relation | J. Infect. Dis., 206(5), 662-668 | en_US |
dc.relation.ispartof | Journal of Infectious Diseases | en_US |
dc.source | AH | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | gamma interferon; hepatitis B core antigen; hepatitis B surface antigen; hepatitis B(e) antigen; toll like receptor 2; toll like receptor 4; toll like receptor 5; toll like receptor 9; adolescent; adult; allele; article; child; cohort analysis; controlled study; cytokine production; cytokine release; female; follow up; gene; genotype; hepatitis B; Hepatitis B virus; heterozygote; human; human cell; major clinical study; male; nonhuman; peripheral blood mononuclear cell; preschool child; priority journal; promoter region; prospective study; seroconversion; single nucleotide polymorphism; Taiwan; toll like receptor 2 gene; toll like receptor 4 gene; toll like receptor 5 gene; toll like receptor 9 gene; viral clearance; virus load; Child; Cohort Studies; DNA; Female; Genetic Variation; Genotype; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Logistic Models; Male; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Prospective Studies; Radioimmunoassay; Taiwan; Toll-Like Receptors; Viral Load | - |
dc.title | Toll-like receptor and hepatitis B virus clearance in chronic infected patients: A long-term prospective cohort study in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/infdis/jis420 | - |
dc.relation.pages | 662-668 | en_US |
dc.relation.journalvolume | 206 | en_US |
dc.relation.journalissue | 5 | en_US |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.orcid | 0000-0001-6343-1658 | - |
crisitem.author.orcid | 0000-0003-4979-3761 | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.orcid | 0000-0002-4074-5838 | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系
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