https://scholars.lib.ntu.edu.tw/handle/123456789/369436
標題: | Monascus purpureus-fermented products and oral cancer: A review | 作者: | Hsu, Wei-Hsuan TZU-MING PAN Pan, Tzu-Ming |
關鍵字: | Metabolite; Monascus purpureus; Oral cancer; Red mold dioscorea; Red mold rice | 公開日期: | 2012 | 卷: | 93 | 期: | 5 | 起(迄)頁: | 1831-1842 | 來源出版物: | Applied Microbiology and Biotechnology | 摘要: | Tobacco and alcohol consumption have been reported as major factors for the development of oral cancer. Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products have many functional secondary metabolites, including monacolin K, citrinin, ankaflavin, and monascin. In several recent studies performed in our laboratory, these secondary metabolites have shown anti-inflammatory, anti-oxidative, and anti-tumor activities. Many published studies have shown the efficacy of Monascus-fermented products in the prevention of numerous types of cancer. The current article discusses and provides evidence to support that Monascus-fermented metabolites may be developed as painting drugs for the mouth to prevent or cure oral carcinogenesis. This is a novel therapeutic approach focusing on tumor growth attenuation to improve patient survival and quality of life. ? 2012 Springer-Verlag. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84857918181&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/369436 |
DOI: | 10.1007/s00253-012-3891-9 | SDG/關鍵字: | Alcohol consumption; Anti-inflammatories; Anti-tumor activities; Citrinin; Major factors; Monascus; Monascus purpureus; Oral cancer; Oral carcinogenesis; Quality of life; Red mold dioscorea; Red mold rice; Secondary metabolites; Traditional Chinese Medicine; Tumor growth; Metabolism; Metabolites; Molds; Diseases; 4 aminobutyric acid; ankaflavin; biological product; celecoxib; cholestin; dimerumic acid; mevinolin; monascin; monascorubrin; red mold dioscorea; rubropunctatin; unclassified drug; xanthomonascin A; yellow II; biotechnology; cancer; disease treatment; drug development; edible species; fermentation; laboratory method; literature review; metabolite; oral health; quality of life; rice; survival; traditional medicine; tumor; antineoplastic activity; cancer survival; carcinogenesis; drug structure; fermented product; human; Monascus purpureus; mouth cancer; nonhuman; oral squamous cell carcinoma; quality of life; short survey; tumor growth; Antineoplastic Agents; Asia; Fermentation; Humans; Monascus; Mouth Neoplasms; Far East; Dioscorea; Fungi; Monascus; Monascus purpureus; Nicotiana tabacum |
顯示於: | 生化科技學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。