https://scholars.lib.ntu.edu.tw/handle/123456789/369529
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chiu, Shu-Chun | en_US |
dc.contributor.author | Hu, Shu-Chia | en_US |
dc.contributor.author | Chang, Chih-Cheng | en_US |
dc.contributor.author | CHIA-YI CHANG | en_US |
dc.contributor.author | Huang, Chin-Cheng | en_US |
dc.contributor.author | VICTOR FEI PANG | en_US |
dc.contributor.author | FUN-IN WANG | en_US |
dc.creator | Chiu, S.-C.;Hu, S.-C.;Chang, C.-C.;Chang, C.-Y.;Huang, C.-C.;Pang, V.F.;Wang, F.-I. | - |
dc.date.accessioned | 2018-09-10T09:16:41Z | - |
dc.date.available | 2018-09-10T09:16:41Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84869864594&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/369529 | - |
dc.description.abstract | Porcine teschoviruses (PTVs) belong to the genus Teschovirus within the family Picornaviridae. Hitherto, PTVs have had 13 serotypes associated with a variety of clinical diseases. The virulent PTV-1 strains were associated with highly fatal, nonsuppurative encephalomyelitis of pigs (Teschen disease) in the 1930-1950s. Today, less virulent Talfan strains of PTV-1 are more widespread, and PTVs have contaminated swine herds worldwide (endemic or enzootic) together with a variety of common swine pathogens (multi-infection status). The aim of this study was to investigate the extent to which PTVs play a role in causing diseases in the field, under the endemic and multi-infection situation, when most pigs in the herds are infected and immune. Based on the fecal-oral model of pathogenesis, a set of 15 organs were collected from 30 culled post-weanling piglets of 4-8 weeks old. For nested RT-PCR targeted on the 5'-NTR, the PTV detection rate was 96.7% (by heads), confirming the endemic status, and infection was most commonly detected in the intestines (averaged 61%) and lymphoid organs (averaged 59%), followed by visceral organs (averaged 37%) and the CNS (different parts varied from 17 to 47%). The correlation of PTVs detected by nested RT-PCR and a histological lesion were analyzed by Chi-square test showing that in the field situation only non-suppurative encephalitis in the caudal part of the brain (P= 0.054) may be marginal significantly attributed to infection by PTVs. By genotyping based on partial VP1 sequences, 5 serotypes, namely PTV-1, -4, -6, -7, and -11, were identified, with some animals having two serotypes co-existed in different organs. © 2012 Elsevier B.V. | - |
dc.language | en | en |
dc.relation.ispartof | Veterinary Microbiology | en_US |
dc.source | AH | - |
dc.subject.mesh | Animals; Genotype; Picornaviridae Infections; Reverse Transcriptase Polymerase Chain Reaction; Swine; Swine Diseases; Teschovirus; Viral Proteins | - |
dc.subject.other | Endemic; Multi-infection; Nonsuppurative encephalitis; Porcine teschovirus | - |
dc.subject.other | Animalia; Peru tomato mosaic virus; Picornaviridae; Porcine teschovirus; Suidae; Sus; Teschovirus | - |
dc.subject.other | animal cell; animal experiment; animal tissue; article; brain; central nervous system; controlled study; encephalitis; gene sequence; genotype; histopathology; intestine; lymph node; nonhuman; reverse transcription polymerase chain reaction; serotype; swine; Teschen disease; Teschovirus; virus detection; viscera | - |
dc.subject.other | protein VP1 | - |
dc.title | The role of porcine teschovirus in causing diseases in endemically infected pigs | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.vetmic.2012.07.031 | - |
dc.identifier.scopus | 2-s2.0-84869864594 | - |
dc.relation.pages | 88-95 | - |
dc.relation.journalvolume | 161 | - |
dc.relation.journalissue | 1-2 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.orcid | 0000-0002-8048-4548 | - |
crisitem.author.orcid | 0000-0001-9597-5182 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
顯示於: | 分子暨比較病理生物學研究所 |
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