Application of autologous mesenchymal stem cells and coenzyme Q10 in a pig model of acute myocardial infarction
Journal
Journal of Animal and Veterinary Advances
Journal Volume
11
Journal Issue
19
Pages
3581-3587
Date Issued
2012
Author(s)
Abstract
The application of antioxidants in order to decrease injures of implanted cells has been an important issue for transplantation therapy. Coenzyme Q10 is widely distributed in animals and humans. It plays an important role in cellular energy production in the mitochondrial respiratory chain. Coenzyme Q10 has been demonstrated to have a potential role in the prevention and treatment of heart diseases by improving cellular bioenergetics. Mesechymal stem cells are a leading candidate for cell-based therapies. Researchers hypothesized that the condition of damaged myocardium could be improved with coenzyme Q10 supplementation therapy. Cell survival rate would be increased due in part to the decreased apoptosis and necrosis of cardiomyocytes in ischemic and reperfusion injures. In this study, a combination therapy of mesechymal stem cells transplantation and coenzyme Ql 0 supplementation for acute myocardial infarct showed promising results in vivo. Left ventricular function was notably improved with only small areas of fibrosis formation. ? Medwell Journals, 2012.
Subjects
Acute myocardial infarction; Cells therapy; Coenzyme Q10; Ischemic; Mesenchymal stem cell; Reperfusion injures
SDGs
Type
journal article