https://scholars.lib.ntu.edu.tw/handle/123456789/370398
標題: | Association of response to hepatitis B vaccination and survival in dialysis patients | 作者: | Lin, S.-Y. Liu, J.-H. Wang, S.-M. Wang, I.-K. CHEN-AN TSAI Liu, Y.-L. Lin, H.-H. Chang, C.-C. Huang, C.-C. |
關鍵字: | Hepatitis B vaccination; Immune response; Post-vaccination anti-HBs titers | 公開日期: | 2012 | 卷: | 13 | 期: | 1 | 來源出版物: | BMC Nephrology | 摘要: | Background: The status of immunocompromised patients is well recognized in end stage renal disease (ESRD). As described recently, this acquired immune dysfunction in the uremic milieu may be one of the main pathogenic factors for mortality in ESRD. The aim of this study was to determine the relationship between the immune response following a hepatitis B vaccination (HBV vaccination) and the survival of maintenance dialysis patients. Methods. A total of 156 patients (103 on hemodialysis and 53 on continuous ambulatory peritoneal dialysis) were recruited. After receiving a full dose of the HBV vaccination, all patients were followed up for to 5years to evaluate the association of patient survival, cause of mortality, and immune response. Results: The response rate to the hepatitis B vaccination was 70.5%. There was no significant association between the immune response and the 5-year survival rate (p =0.600) or between the post-vaccination anti-HBs titers and the 5-year survival rate (p=0.201). The logistic prediction model with the coefficient as non-response following HBV vaccination, diabetes mellitus, old age, and low albumin level could significantly predict infection-cause mortality (sensitivity=0.842, specificity=0.937). Conclusion: There was no significant association between the immune response to HBV vaccination and the 5-year survival rate. However, non-response following HBV vaccination might be associated with infection-cause mortality in dialysis patients. ? 2012 Lin et al.; licensee BioMed Central Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84865502965&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/370398 |
DOI: | 10.1186/1471-2369-13-97 | SDG/關鍵字: | albumin; hepatitis B antibody; hepatitis B vaccine; adult; aged; antibody titer; article; continuous ambulatory peritoneal dialysis; diabetes mellitus; female; follow up; hemodialysis patient; hepatitis B; human; immune response; kidney failure; logistic regression analysis; major clinical study; male; mortality; sensitivity and specificity; survival rate; treatment response; Causality; Comorbidity; Female; Hepatitis B Vaccines; Humans; Immune System Diseases; Incidence; Male; Middle Aged; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors; Survival Analysis; Survival Rate; Taiwan; Treatment Outcome; Vaccination |
顯示於: | 農藝學系 |
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