https://scholars.lib.ntu.edu.tw/handle/123456789/370871
標題: | Steroids from the soft coral Sinularia crassa | 作者: | Chao, C.-H. Chou, K.-J. Huang, C.-Y. Wen, Z.-H. Hsu, C.-H. Wu, Y.-C. CHANG-FENG DAI Sheu, J.-H. |
關鍵字: | Anti-inflammatory activity; Crassarosterol A; Crassarosterosides A-D; O-tolylthiocarbamate; Sinularia crassa | 公開日期: | 2012 | 卷: | 10 | 期: | 2 | 起(迄)頁: | 439-450 | 來源出版物: | Marine Drugs | 摘要: | One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A-D (2-5) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher's method. The absolute configurations for the sugar moieties of 2-5 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis. Compounds 2 and 4 could significantly inhibit the expression of pro-inflammatory iNOS protein at 10 ?M. In contrast, 1-3 were found to stimulate the expression of COX-2 protein at this concentration. Steroids 1 and 4 also showed cytotoxicity toward the selected human liver cancer cells. ? 2012 by the authors; licensee MDPI. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84863287330&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/370871 |
DOI: | 10.3390/md10020439 | SDG/關鍵字: | crassarosterol A; crassarosteroside A; crassarosteroside B; crassarosteroside C; crassarosteroside D; cyclooxygenase 2; inducible nitric oxide synthase; natural product; steroid; unclassified drug; antiinflammatory activity; antineoplastic activity; article; cancer cell; concentration response; controlled study; coral; drug cytotoxicity; drug determination; drug hydrolysis; drug isolation; drug structure; high performance liquid chromatography; human; human cell; liver cancer; protein expression; Sinularia crassa; structure analysis; Alcyonacea; Sinularia |
顯示於: | 海洋研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。