https://scholars.lib.ntu.edu.tw/handle/123456789/370873
標題: | Sarcocrassocolides M-O, bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule | 作者: | Lin, W.-Y. Lu, Y. Chen, B.-W. Huang, C.-Y. Su, J.-H. Wen, Z.-H. CHANG-FENG DAI Kuo, Y.-H. Sheu, J.-H. |
關鍵字: | Anti-inflammatory activity; Cytotoxic activity; Sarcophyton crassocaule; Soft coral | 公開日期: | 2012 | 卷: | 10 | 期: | 3 | 起(迄)頁: | 617-626 | 來源出版物: | Marine Drugs | 摘要: | Three new cembranoids, sarcocrassocolides M-O (1-3), have been isolated from the soft coral Sarcophyton crassocaule . The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1-3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. ? 2012 by the authors; licensee MDPI. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84859566922&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/370873 |
DOI: | 10.3390/md10030617 | SDG/關鍵字: | antiinflammatory agent; cembranoid; cyclooxygenase 2; cytotoxic agent; drug metabolite; inducible nitric oxide synthase; lipopolysaccharide; mitomycin C; Sarcocrassocolide M; Sarcocrassocolide N; Sarcocrassocolide O; unclassified drug; antiinflammatory activity; article; cancer cell culture; concentration response; controlled study; coral; drug cytotoxicity; drug determination; drug effect; drug isolation; drug structure; enzyme inhibition; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; human; human cell; macrophage; nonhuman; nuclear Overhauser effect; photon correlation spectroscopy; protein expression; Sarcophyton crassocaule; stereochemistry; Taiwan; upregulation; Alcyonacea; Sarcophyton crassocaule |
顯示於: | 海洋研究所 |
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