https://scholars.lib.ntu.edu.tw/handle/123456789/372885
標題: | Prebiotic effect of diosgenin, an immunoactive steroidal sapogenin of the Chinese yam | 作者: | Huang, Chung-Hsiung Cheng, Jin-Yi Deng, Ming-Chung CHUNG-HSI CHOU TONG-RONG JAN |
關鍵字: | Chinese yam; Diosgenin; Lactobacillus; Prebiotic; Sapogenin | 公開日期: | 2012 | 卷: | 132 | 期: | 1 | 起(迄)頁: | 428-432 | 來源出版物: | Food Chemistry | 摘要: | This study investigated the effect of diosgenin, a yam-derived phytochemical, on the growth of enteric lactic acid bacteria (LAB). The in vivo effect of diosgenin on the density of intestinal flora was examined in a murine model of food allergy. Oral administration with diosgenin markedly restored the diminished density of faecal LAB associated with allergic reactions. The direct effect of diosgenin and several structure-related steroidal compounds on the growth of faecal anaerobes isolated from diosgenin-administered mice was also investigated. The presence of diosgenin significantly enhanced the growth of Lactobacillus murinus and Lactobacillus reuteri, but not enterococci. Structure-activity relationship analysis showed that the prebiotic activity of steroidal sapogenins might require structural elements of the C5-C6 double bond and intact E- and F-rings. Collectively, these results indicate that steroidal sapogenins may be a novel class of prebiotics to LAB. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84355161976&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/372885 |
DOI: | 10.1016/j.foodchem.2011.11.016 | SDG/關鍵字: | animal experiment; animal model; article; bacterium culture; bacterium identification; controlled study; Dioscorea opposita; Enterococcus faecium; Enterococcus hirae; feces microflora; food allergy; in vivo study; intestine flora; lactic acid bacterium; lactobacillus murinus; Lactobacillus reuteri; medicinal plant; mouse; nonhuman; nucleotide sequence; structure activity relation; animal; Bagg albino mouse; chemistry; drug effects; feces; growth, development and aging; intestine; Lactobacillus; male; microbiology; plant tuber; yam |
顯示於: | 獸醫學系 |
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