https://scholars.lib.ntu.edu.tw/handle/123456789/375898
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kuen-Feng Chen | en |
dc.creator | Hou, D.-R. and Huang, A.-C. and Shiau, C.-W. and Wang, C.-Y. and Yu, H.-C. and Chen, K.-F. | - |
dc.date.accessioned | 2018-09-10T09:39:53Z | - |
dc.date.available | 2018-09-10T09:39:53Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84890904236&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/375898 | - |
dc.description.abstract | CIP2A is an oncoprotein that upregulates p-Akt and promotes cancer cell proliferation and survival. The proteasome inhibitor bortezomib has been shown to reduce CIP2A and lead to cell apoptosis. Here; we modified the functional group of bortezomib to generate a series of novel compounds and conducted a structure-activity relationship (SAR) study. The results showed that compound 1 was able to repress CIP2A expression and cell apoptosis in the same manner as bortezomib, but with less potency in inhibition of proteasome activity. This finding provides a new direction for the design of CIP2A inhibitors. ? 2013 by the authors; licensee MDPI, Basel, Switzerland. | - |
dc.language | en | en |
dc.relation.ispartof | Molecules | en_US |
dc.source | AH | - |
dc.subject | Apoptosis; Bortezomib; CIP2A | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antineoplastic agent; autoantigen; boronic acid derivative; bortezomib; KIAA1524 protein, human; membrane protein; pyrazine derivative; apoptosis; article; cell proliferation; cell survival; chemical structure; chemistry; drug antagonism; drug effect; gene silencing; genetics; human; IC 50; liver cell carcinoma; liver tumor; metabolism; structure activity relation; synthesis; tumor cell line; Antineoplastic Agents; Apoptosis; Autoantigens; Boronic Acids; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Knockdown Techniques; Humans; Inhibitory Concentration 50; Liver Neoplasms; Membrane Proteins; Molecular Structure; Pyrazines; Structure-Activity Relationship | - |
dc.title | Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition | - |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/molecules181215398 | - |
dc.relation.pages | 15398-15411 | - |
dc.relation.journalvolume | 18 | - |
dc.relation.journalissue | 12 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Medical Research | - |
crisitem.author.orcid | 0000-0002-4686-7019 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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