https://scholars.lib.ntu.edu.tw/handle/123456789/376170
標題: | Focal foveal atrophy of unknown etiology: Clinical pictures and possible underlying causes | 作者: | Kao, Tzu-Yun MUH-SHY CHEN Jou, Jieh-Ren CHANG-PING LIN TZU-HSUN TSAI TZYY-CHANG HO |
關鍵字: | Focal foveal atrophy; Optical coherence tomography; Visual function | 公開日期: | 2015 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: Focal foveal atrophy is defined as the presence of a small, focal, ill-defined, hypopigmented foveal or juxtafoveal lesion, with the remaining retina unaffected. The purpose of this study was to report the clinical characteristics and optical coherence tomography (OCT) in patients with focal foveal atrophy of unknown etiology. Methods: The study was a retrospective observational case series. Data collected included complete ocular examination results for best corrected visual acuity (BCVA), ophthalmoscopy, fundus photography, fluorescein angiography, color sense discrimination tests, visual field tests, and OCT examinations. Results: Twenty-three eyes in 21 patients were examined. The mean patient age was 49.2±15.4 years. The mean BCVA was 20/25. The 21 patients were divided into three groups according to OCT results. Group 1 eyes (n=10) had intact inner and outer hyperreflective layers (HRLs), with the signal of the inner HRL corresponding to the junction between the inner and outer photoreceptor segments and the outer HRL corresponding to the retinal pigment epithelium (RPE). Group 2 eyes (n=9) had small hyporeflective defects with defects in the inner HRL at the fovea but an intact outer HRL. Group 3 eyes (n=4) had small hyporeflective defects in both the inner and outer HRLs at the fovea. Groups 3 eyes had significantly lower visual acuity compared to Group 1 eyes and Group 2 eyes. There was no significant difference in visual acuity between Group 1 and Group 2 eyes. There were no significant differences among the groups with respect to color vision or foveal thickness. Conclusion: This is the first report of clinical presentations for patients with focal foveal atrophy of unknown etiology. OCT aided in the diagnosis and assessment of the degree of retinal structural abnormalities, but the real etiology of foveal atrophy remains unclear. ? 2012. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84876095262&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/376170 |
DOI: | 10.1016/j.jfma.2012.11.011 | SDG/關鍵字: | adult; Article; atrophy; blurred vision; clinical article; color vision test; diplopia; esthenopsia; eye examination; female; fluorescence angiography; focal foveal atrophy; human; idiopathic disease; male; metamorphopsia; middle aged; ophthalmoscopy; optical coherence tomography; perimetry; pigment epithelium; retina disease; retinal thickness; visual acuity; visual disorder; adolescent; aged; atrophy; child; color vision; optical coherence tomography; pathology; retina fovea; Retinal Diseases; retrospective study; Taiwan; visual acuity; young adult; Adolescent; Adult; Aged; Atrophy; Child; Color Vision; Female; Fluorescein Angiography; Fovea Centralis; Humans; Male; Middle Aged; Retinal Diseases; Retrospective Studies; Taiwan; Tomography, Optical Coherence; Visual Acuity; Young Adult |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。