DC 欄位 | 值 | 語言 |
dc.contributor | 臺大醫院-小兒部;臺大醫院-病理部;臺大醫學院-一般醫學科;臺大醫學院-病理學科暨研究所;臺大醫學院-臨床醫學研究所; | en |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.contributor.author | YUNG-MING JENG | en_US |
dc.contributor.author | Chiang, Cheng-Lun | en_US |
dc.contributor.author | HUEY-LING CHEN | en_US |
dc.contributor.author | JIA-FENG WU | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.creator | Hsu, Hong-Yuan;Chang, Mei-Hwei;Ni, Yen-Hsuan;Jeng, Yung-Ming;Chiang, Cheng-Lun;Chen, Huey-Ling;Wu, Jia-Feng;Chen, Pei-Jer | en |
dc.creator | Hsu, Hong-Yuan;Chang, Mei-Hwei;Ni, Yen-Hsuan;Jeng, Yung-Ming;Chiang, Cheng-Lun;Chen, Huey-Ling;Wu, Jia-Feng;Chen, Pei-Jer | en |
dc.creator | Hsu, H.-Y. and Chang, M.-H. and Ni, Y.-H. and Jeng, Y.-M. and Chiang, C.-L. and Chen, H.-L. and Wu, J.-F. and Chen, P.-J. | - |
dc.creator | 鄭永銘 ;倪衍玄 ;張美惠 ;許宏遠 ;吳嘉峰 ;陳培哲 ;陳慧玲 | zh-tw |
dc.creator | 鄭永銘;倪衍玄;張美惠;許宏遠;吳嘉峰;陳培哲;陳慧玲 | zh-tw |
dc.date.accessioned | 2018-09-10T09:40:34Z | - |
dc.date.available | 2018-09-10T09:40:34Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84874735359&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/376188 | - |
dc.description.abstract | Background. The long-term evolution and outcomes of infection with a hepatitis B virus (HBV) surface antigen (HBsAg) gene mutant (hereafter, "HBsAg-mutant HBV") among immunized children remain unclear.Methods. Ninety-five HBsAg-positive children aged 0.5-18.4 years (mean age, 5.8 years) who did not respond to postnatal immunoprophylaxis were prospectively followed for 1-22.8 years (mean follow-up, 8.5 years). Clinical, serologic, and virologic features were compared between 38 untreated HBV e antigen (HBeAg)-positive children carrying HBsAg-mutant HBV (group 1) and 49 children carrying wild-type HBV (group 2). HBsAg-mutant HBV was examined in 20 immunized children presenting with HBV-related hepatocellular carcinoma (HCC).Results. The initial alanine aminotransferase (ALT) level, the maximal ALT level during the HBeAg-positive phase of HBV infection, the cumulative incidence of HBeAg seroconversion (P =. 0018), and the rate of low serum HBV DNA load (defined as <104 copies/mL) at the last visit (P =. 006) were higher in group 1 than in group 2. A higher frequency of HBV genotype C and a higher ALT level during surface mutant viremia were observed in codon 110-129 mutants than in codon 144-145 mutants. None of the 95 patients developed cirrhosis or HCC. HBsAg-mutant HBV was detected in 3 of 8 (38%) HBV DNA-positive children with HCC.Conclusions. HBeAg-positive immunized children carrying HBsAg-mutant HBV may develop hepatitis activity, HBeAg seroconversion, and a low viremic state earlier than those carrying wild-type HBV. Continuous monitoring of children with wild-type HBV infection and those with HBsAg-mutant HBV for possible development of HCC is needed. ? 2013 The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. | en_US |
dc.format.extent | 103 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en | en |
dc.relation | J. Infect. Dis., 207(7), 1047-1057 | en_US |
dc.relation.ispartof | Journal of Infectious Diseases | en_US |
dc.source | AH | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; hepatitis B surface antigen; hepatitis B vaccine; hepatitis B(e) antigen; virus DNA; adolescent; adult; alanine aminotransferase blood level; article; blood sampling; child; clinical feature; codon; female; follow up; genotype; hepatitis B; Hepatitis B virus; human; human tissue; immunoprophylaxis; incidence; infant; liver cell carcinoma; long term care; major clinical study; male; outcome assessment; preschool child; priority journal; school child; seroconversion; treatment duration; treatment failure; virus detection; virus load | - |
dc.title | Long-term follow-up of children with postnatal immunoprophylaxis failure who were infected with hepatitis B virus surface antigen gene mutant | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/infdis/jis943 | - |
dc.relation.pages | 1047-1057 | en_US |
dc.relation.journalvolume | 207 | en_US |
dc.relation.journalissue | 7 | en_US |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.orcid | 0000-0002-3878-4491 | - |
crisitem.author.orcid | 0000-0002-4074-5838 | - |
crisitem.author.orcid | 0000-0001-6343-1658 | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學教育暨生醫倫理學科所
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