https://scholars.lib.ntu.edu.tw/handle/123456789/377115
標題: | Red mold dioscorea decreases blood pressure when administered alone or with amlodipine and is a potentially safe functional food in SHR and WKY rats | 作者: | TZU-MING PAN | 關鍵字: | Amlodipine; Hypertension; Monascus purpureus NTU 568; Red mold dioscorea; Rhabdomyolysis | 公開日期: | 2013 | 卷: | 5 | 期: | 3 | 起(迄)頁: | 1456-1465 | 來源出版物: | Journal of Functional Foods | 摘要: | Hypertension is a risk factor for metabolic syndromes and cardiovascular diseases. Statins are antihypertensive, but can cause rhabdomyolysis as a side effect, which involves the breakdown of muscle fibres and release of myoglobin into the bloodstream. In this study, we used hypertensive rats to investigate whether the interaction between Monascus-fermented products (red mold dioscorea; RMD) and amlodipine increases the risk of rhabdomyolysis and toxicity. A single oral dose of RMD (176. mg/kg) significantly decreased systolic blood pressure (SBP) and diastolic blood pressure (DBP). Moreover, administration of RMD, alone or in combination with amlodipine, did not cause significant rhabdomyolysis and did not impair the metabolic or physiological functions of the liver or kidney. RMD treatment had hypocholesterolemic and hypotriacylglycerolemic effects, indicating that RMD may prevent the incidence of atherosclerosis. The findings of this study lend support to the potential use of RMD as a novel therapeutic and antihypertensive functional food. ? 2013 Elsevier Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84880513597&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/377115 |
DOI: | 10.1016/j.jff.2013.06.003 | SDG/關鍵字: | Dioscorea; Dioscorea alata; Monascus; Monascus purpureus; Rattus |
顯示於: | 生化科技學系 |
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