https://scholars.lib.ntu.edu.tw/handle/123456789/377336
DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHEN-HSUAN LIU | en |
dc.creator | Liu, J.-L. and Chang, K.-C. and Lo, C.-C. and Chu, P.-Y. and Liu, C.-H. | - |
dc.date.accessioned | 2018-09-10T09:42:55Z | - |
dc.date.available | 2018-09-10T09:42:55Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84875947640&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/377336 | - |
dc.description.abstract | Background: Autophagy is a self-catabolic mechanism that degrades unnecessary cellular components through lysosomal enzymes. Beclin-1, an autophagy-related protein, establishes the first connection between autophagy and tumorigenesis. The purpose of this study is to assess the Beclin-1 expression pattern and to determine its prognostic significance in patients with malignant canine mammary tumor (CMT). Results: We examined Beclin-1 expression in 70 cases of malignant CMTs by immunohistochemistry. Cytoplasmic Beclin-1 expression was significantly weaker in cancer cells than in nearby normal mammary glands (p < 0.001). Low cytoplasmic expression (57.14%) was associated with older age, lower degree of tubular formation, increased mitotic activity, higher histologic grade, and extensive necrosis. Low nuclear expression (40%) was connected with older age, lower degree of tubular formation, extensive necrosis, and negative for Her2/neu overexpression. Univariate survival analysis showed that Beclin-1 cytoplasmic expression was a poor prognostic factor for overall survival rate (p < 0.001). Multivariate survival analysis demonstrated that Beclin-1 cytoplasmic expression is an independent prognostic factor (p = 0.016).Conclusions: Loss of Beclin-1 is associated with aggressive clinicopathologic features and poor overall survival. The results suggest that Beclin-1 plays an important role in tumor progression of malignant CMTs. ? 2013 Liu et al.; licensee BioMed Central Ltd. | - |
dc.language | en | en |
dc.relation.ispartof | BMC Veterinary Research | en_US |
dc.source | AH | - |
dc.subject | Autophagy; Beclin-1; Canine mammary tumor; Immunohistochemistry | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | apoptosis regulatory protein; apoptosis regulatory protein; age; animal; carcinoma; dog; Dog Diseases; female; Mammary Neoplasms, Animal; metabolism; pathology; prognosis; sarcoma; survival; udder; veterinary; animal disease; article; dog disease; experimental mammary neoplasm; metabolism; Age Factors; Animals; Apoptosis Regulatory Proteins; Carcinoma; Dog Diseases; Dogs; Female; Mammary Glands, Animal; Mammary Neoplasms, Animal; Prognosis; Sarcoma; Survival Analysis; Age Factors; Animals; Apoptosis Regulatory Proteins; Carcinoma; Dog Diseases; Dogs; Female; Mammary Glands, Animal; Mammary Neoplasms, Animal; Prognosis; Sarcoma; Survival Analysis | - |
dc.title | Expression of autophagy-related protein beclin-1 in malignant canine mammary tumors | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/1746-6148-9-75 | - |
dc.relation.journalvolume | 9 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.orcid | 0000-0002-6109-5707 | - |
Appears in Collections: | 分子暨比較病理生物學研究所 |
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