High-throughput physically based approach for mammalian cell encapsulation
Journal
Applied Physics Letters
Journal Volume
103
Journal Issue
15
Date Issued
2013
Author(s)
Abstract
Herein, we wish to tear down the traditional boundaries between physics and life sciences by demonstrating a physically based, flow-focusing method to encapsulate mammalian cells into alginate-based microspheres in a very short period of time. We paid particular attention to the physical properties of the alginate solution as it was critical to create a physiologically relevant environment within the alginate microspheres. The cells we cultured when re-culturing them on Petri dishes could still be maintained for at least 4 days after microsphere encapsulation. We believe that this study would provide interesting insight in biophysics, polymer physics, and applied physics. © 2013 AIP Publishing LLC.
SDGs
Type
journal article