Cytotoxic and anti-inflammatory eunicellin-based diterpenoids from the soft coral Cladiella krempfi
Journal
Marine Drugs
Journal Volume
11
Journal Issue
3
Pages
788-799
Date Issued
2013
Author(s)
Abstract
Five new eunicellin-based diterpenoids, krempfielins E-I (1-5) and seven known compounds (6-12) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. Metabolites 5, 6, 10 and 12 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 6 and 10 could potently inhibit the accumulation of the pro-inflammatory iNOS protein, and 6 and 12 could significantly reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells. ? 2013 by the authors.
Subjects
Anti-inflammatory agents; Cladiella krempfi; Cytotoxicity; Eunicellin-based diterpenoids
SDGs
Other Subjects
3 acetoxycladiell 7(16),11(17) dien 6 ol; 6 acetoxy litophynin E; 6 methyl ether of litophynol B; cyclooxygenase 2; diterpenoid; inducible nitric oxide synthase; krempfielin E; krempfielin F; krempfielin G; krempfielin H; krempfielin I; litophynin F; litophynin I monoacetate; natural product; sclerophytin a; sclerophytin b; unclassified drug; animal cell; antiinflammatory activity; article; cancer cell culture; Cladiella krempfi; controlled study; coral; drug cytotoxicity; drug potency; drug screening; drug structure; human; human cell; nonhuman; protein expression; spectroscopy; Taiwan; Alcyonacea; Cladiella
Type
journal article