https://scholars.lib.ntu.edu.tw/handle/123456789/382258
標題: | Lipid profiles in children with and without asthma: Interaction of asthma and obesity on hyperlipidemia | 作者: | YUNG-LING LEE | 關鍵字: | Asthma; Children; Hyperlipidemia; Metabolic syndrome; Obesity | 公開日期: | 2013 | 卷: | 7 | 期: | 1 | 起(迄)頁: | 20-25 | 來源出版物: | Diabetes and Metabolic Syndrome: Clinical Research and Reviews | 摘要: | Aims: The joint effect of obesity and asthma on hyperlipidemia has never been explored. We aim to examine (1) the association of dyslipidemia and asthma, (2) the interaction effect of asthma and obesity on hyperlipidemia, and (3) whether a gender difference existed in the above relationships. Methods: Between 2009 and 2010, 10- to 15-year-old children were recruited from 7 schools and 2 hospitals in Northern Taiwan. The population consisted of 237 asthmatic children and 225 non-asthmatic controls, and was further divided into four groups: non-obese controls, obese controls, non-obese asthmatics, and obese asthmatics. Measurements included anthropometric measures and blood samples for analysis of metabolic factors. The Cook's criteria were used to define childhood metabolic syndrome. General linear models were used to analyze how lipid profiles were associated with obesity and asthma. Results: Total cholesterol and low density lipoprotein cholesterol levels increased progressively in the group order obese asthmatics > non-obese asthmatics > obese controls > non-obese controls. In boys, low density lipoprotein cholesterol levels were significantly higher in obese asthmatics compared to obese non-asthmatics, with a mean difference of 6.2 mmol/L in the general linear model. We also discovered a significant interactive effect of obesity and asthma on hyperlipidemia in boys (p for interaction = 0.03). Conclusions: Asthma was associated with higher low density lipoprotein cholesterol levels and this association was amplified in overweight and obese subjects. A gender difference was observed in the joint effect of obesity and asthma on hyperlipidemia. ? 2013 Diabetes India. Published by Elsevier Ltd. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84875366639&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/382258 |
DOI: | 10.1016/j.dsx.2013.02.026 | SDG/關鍵字: | glucose; high density lipoprotein cholesterol; lipid; low density lipoprotein cholesterol; triacylglycerol; adolescent; anthropometry; article; asthma; blood sampling; body mass; child; childhood obesity; controlled study; corticosteroid therapy; disease association; family history; female; glucose blood level; hip circumference; human; hyperlipidemia; lipid blood level; major clinical study; male; metabolic syndrome X; priority journal; school child; sex difference; Taiwan; triacylglycerol blood level; waist circumference; waist hip ratio; Adolescent; Asthma; Blood Glucose; Body Mass Index; Child; Coronary Artery Disease; Cross-Sectional Studies; Female; Hospitals; Humans; Hyperlipidemias; Inflammation; Linear Models; Lipids; Male; Metabolic Syndrome X; Obesity; Questionnaires; Schools; Sex Distribution; Taiwan |
顯示於: | 流行病學與預防醫學研究所 |
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