https://scholars.lib.ntu.edu.tw/handle/123456789/383548
標題: | Comparison of benign lesion regression following vocal fold steroid injection and vocal hygiene education | 關鍵字: | dexamethasone; larynx; nodules; occupational; Polyp; triamcinolone; vocal demand | 公開日期: | 2014 | 卷: | 124 | 期: | 2 | 起(迄)頁: | 510-515 | 來源出版物: | Laryngoscope | 摘要: | Objectives/Hypothesis This study intends to objectively quantify and compare the regression rates of vocal lesions in patients receiving either vocal fold steroid injection (VFSI) or vocal hygiene education (VHE). Potential influence of occupational vocal demands on the treatment outcome was also investigated. Study Design Retrospective case series. Methods This study enrolled 176 patients of vocal nodules and vocal polyps. Ninety-two patients received VFSI, while 84 patients received VHE. We measured the lesion area with correction by the length of vocal fold, according to videolaryngoscopic examinations before treatment and 1 and 2 months after treatment. Results VFSI was associated with a higher lesion reduction rate than VHE at 1 and 2 months (P <0.05). In vocal nodules and patients with ordinary occupational vocal demands, VFSI achieved a higher lesion regression rate than VHE at 1 month (P <0.05), while both modalities resulted in similar lesion reduction rates at 2 months (P >0.05). In vocal polyps, the lesion reduction rate after VFSI was higher than that following VHE at 1 and 2 months (P <0.01). In patients with high occupational vocal demands, the lesion sizes decreased significantly at 1 and 2 months following VFSI (P <0.01), but not for those receiving VHE (P >0.05). Conclusions VHE remains the fundamental strategy for all dysphonic patients, while VFSI can be applied alternatively. Both VFSI and VHE are effective for vocal nodules and patients with ordinary occupational vocal demands, but VFSI achieves lesion regression earlier than VHE. VFSI is preferred over VHE for vocal polyps and patients with high occupational vocal demands. Level of Evidence 4. Copyright ? 2013 The American Laryngological, Rhinological and Otological Society, Inc. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84892903421&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/383548 |
DOI: | 10.1002/lary.24328 | SDG/關鍵字: | dexamethasone sodium phosphate; triamcinolone acetonide; dexamethasone; glucocorticoid; triamcinolone; adult; aged; article; camera; clinical effectiveness; controlled study; education; female; flexible nasopharyngoscope; human; injection; laryngoscopy; laryngostroboscope; larynx surgery; major clinical study; male; middle aged; needle; priority journal; steroid therapy; treatment outcome; videolaryngostroboscopy; vocal cord disorder; vocal fold steroid injection; vocal hygiene education; vocal nodule; vocal polyp; young adult; comparative study; intralesional drug administration; Laryngeal Diseases; multimodality cancer therapy; patient education; Polyps; remission; retrospective study; vocal cord; Adult; Aged; Combined Modality Therapy; Dexamethasone; Female; Glucocorticoids; Humans; Injections, Intralesional; Laryngeal Diseases; Male; Middle Aged; Patient Education as Topic; Polyps; Remission Induction; Retrospective Studies; Triamcinolone; Vocal Cords; Young Adult |
顯示於: | 流行病學與預防醫學研究所 |
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