https://scholars.lib.ntu.edu.tw/handle/123456789/383648
標題: | Role of neutrophil extracellular traps following injury | 作者: | Liu, Fu-Chao YUEH-HSUN CHUANG Tsai, Yung-Fong Yu, Huang-Ping |
關鍵字: | injury; Neutrophil extracellular trap | 公開日期: | 2014 | 卷: | 41 | 期: | 6 | 起(迄)頁: | 491-498 | 來源出版物: | Shock | 摘要: | Neutrophil extracellular traps (NETs), which consist of neutrophil DNA and cytoplasmic proteins, have been shown to be involved in various infectious, inflammatory, and autoimmune diseases. Neutrophil extracellular traps are abundant at the site of infection and acute inflammation. Neutrophil extracellular trap formation can occur through various intracellular signaling pathways, including peptidylarginine deiminase 4, Raf-MEK-ERK, nitric oxide, Toll-like receptor 4, high mobility group box 1, pentraxin 3, and mammalian targets of rapamycin. A growing body of evidence indicates that NETs may play an important role in injury, and decreases in NETs could reduce tissue injury. Neutrophil extracellular traps are believed to modulate the inflammatory and immune responses of individuals after injury. In this review, the role of NETs in injury, including traumatic injury, ischemia-reperfusion-induced injury, and sepsis, as well as the potential markers and therapeutic targets of NET-related injury will be discussed. Copyright ? 2014 by the Shock Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84901405851&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/383648 |
DOI: | 10.1097/SHK.0000000000000146 | SDG/關鍵字: | deoxyribonuclease; high mobility group B1 protein; histone; mammalian target of rapamycin; mek protein; membrane protein; mitogen activated protein kinase; nitric oxide; pentraxin 3; peptidylarginine deiminase 4; protein arginine deiminase; Raf protein; reduced nicotinamide adenine dinucleotide phosphate oxidase; unclassified drug; human; neutrophil; neutrophil extracellular trap; nonhuman; organ injury; reperfusion injury; review; sepsis; signal transduction; thrombocyte; tissue injury; animal; extracellular trap; injury; pathophysiology; physiology; Animals; Extracellular Traps; Humans; Signal Transduction; Wounds and Injuries |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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