https://scholars.lib.ntu.edu.tw/handle/123456789/383971
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SHING-HWA LIU | en |
dc.creator | Chang, H.-C. and Tai, Y.-T. and Cherng, Y.-G. and Lin, J.-W. and Liu, S.-H. and Chen, T.-L. and Chen, R.-M. | - |
dc.date.accessioned | 2018-09-10T14:51:54Z | - |
dc.date.available | 2018-09-10T14:51:54Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-84898977561&partnerID=MN8TOARS | - |
dc.identifier.uri | http://scholars.lib.ntu.edu.tw/handle/123456789/383971 | - |
dc.description.abstract | The blood-brain barrier (BBB) maintains brain microenvironment. Our previous study showed that oxidized low-density lipoprotein (oxLDL) can damage the BBB by inducing apoptosis of cerebrovascular endothelial cells. This study was aimed at evaluating the effects of resveratrol on high-fat diet-induced insults to the BBB and brain neurons. Exposure of mice to a high-fat diet for 8 weeks increased levels of serum total cholesterol (146 ± 13) and LDL (68 ± 8), but resveratrol decreased such augmentations (119 ± 6; 45 ± 8). Permeability assays showed that a high-fat diet induced breakage of the BBB (88 ± 21). Meanwhile, resveratrol alleviated this interruption (16 ± 6). Neither resveratrol nor a high-fat diet caused the death of cerebrovascular endothelial cells. Instead, exposure to a high-fat diet disrupted the polymerization of occludin and zonula occludens (ZO)-1, but resveratrol significantly attenuated those injuries. Neither a high-fat diet nor resveratrol changed the levels of occludin or ZO-1 in brain tissues. Resveratrol protected brain neurons against high-fat diet-induced caspase-3 activation and genomic DNA fragmentation. This study shows that resveratrol can attenuate the high-fat diet-induced disruption of the BBB via interfering with occludin and ZO-1 tight junctions, and protects against apoptotic insults to brain neurons. ? 2014 American Chemical Society. | - |
dc.language | en | en |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | en_US |
dc.source | AH | - |
dc.subject | blood-brain barrier; brain neurons; high-fat diet; resveratrol; tight junction | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Blood; Cell death; Endothelial cells; Living systems studies; Neurons; Nutrition; Blood; Cell death; Endothelial cells; Living systems studies; Neurons; Resveratrol; Blood-brain barrier; Brain neurons; Caspase-3 activation; High-fat diet; Microenvironments; Oxidized low-density lipoproteins (oxLDL); Tight junctions; Total cholesterols; Resveratrol; Nutrition; Mus; resveratrol; stilbene derivative; animal; apoptosis; article; blood brain barrier; brain; brain atherosclerosis; cytology; drug effect; fat intake; human; Institute for Cancer Research mouse; lipid diet; male; metabolism; mouse; nerve cell; pathophysiology; Animals; Apoptosis; Blood-Brain Barrier; Brain; Diet, High-Fat; Dietary Fats; Humans; Intracranial Arteriosclerosis; Male; Mice; Mice, Inbred ICR; Neurons; Stilbenes | - |
dc.title | Resveratrol attenuates high-fat diet-induced disruption of the blood-brain barrier and protects brain neurons from apoptotic insults | - |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/jf403286w | - |
dc.relation.pages | 3466-3475 | - |
dc.relation.journalvolume | 62 | - |
dc.relation.journalissue | 15 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.orcid | 0000-0002-9976-1197 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 毒理學研究所 |
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