https://scholars.lib.ntu.edu.tw/handle/123456789/384091
標題: | Pregnancy-associated breast cancer in Taiwanese women: Potential treatment delay and impact on survival | 作者: | YA-LING YANG KIN-WEI CHAN FON-JOU HSIEH Chang, Li-Yun MING-YANG WANG |
公開日期: | 2014 | 卷: | 9 | 期: | 11 | 來源出版物: | PLoS ONE | 摘要: | This study investigated the clinicopathologic characteristics and survival of women diagnosed with pregnancy-associated breast cancer (PABC) in Taiwan. PABC is defined as breast cancer diagnosed during pregnancy or within 1 year after obstetric delivery. Our sample of PABC patients (N=26) included all patients diagnosed at a major medical center in northern Taiwan from 1984 through 2009. Among these patients, 15 were diagnosed during pregnancy and 11 were diagnosed within 1 year after delivery. The comparison group included 104 patients within the same age range as the PABC patients and diagnosed with breast cancer not associated with pregnancy from 2004 through 2009 at the same hospital. Patients' initiating treatment delayed, 5-year and 10-year overall survival were delineated by stratified Kaplan-Meier estimates. Patients' characteristics were associated with initiating treatment delayed was evaluated with multivariate proportional hazards modeling. Antepartum PABC patients were younger and had longer time between diagnosis and treatment initiation than postpartum PABC patients. The predictor of treatment delayed was including birth parity, cancer stage, and pregnancy. The PABC group had larger tumors, more advanced cancer stage, and tumors with less progesterone receptor than the comparison group. The antepartum PABC patients had higher mortality than postpartum PABC and comparison groups within 5 years after diagnosis. Based on these results, we confirmed that pregnant women with breast cancer were more likely to delay treatment. Therefore, we recommend that breast cancer screening should be integrated into the prenatal and postnatal routine visits for early detection of the women's breast problems ? 2014 Yang et al. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84912117865&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/384091 |
DOI: | 10.1371/journal.pone.0111934 | SDG/關鍵字: | progesterone receptor; adult; Article; breast cancer; cancer screening; cancer staging; cancer survival; clinical article; clinical feature; controlled study; female; histopathology; human; Kaplan Meier method; mortality; overall survival; parity; postnatal care; pregnancy; pregnancy associated breast cancer; pregnant woman; prenatal care; proportional hazards model; puerperium; Taiwanese; therapy delay; tumor volume; pathophysiology; Pregnancy Complications, Neoplastic; survival; Taiwan; Adult; Female; Humans; Pregnancy; Pregnancy Complications, Neoplastic; Survival Analysis; Taiwan |
顯示於: | 護理學系所 |
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