Evaluation of allelic strength of human TET2 mutations and cooperation between Tet2 knockdown and oncogenic Nras mutation
Journal
British Journal of Haematology
Journal Volume
166
Journal Issue
3
Pages
461-465
Date Issued
2014
Author(s)
Chang, Y.-I.
Subjects
5hmc; Chronic myelomonocytic leukaemia; Oncogenic RAS; TET2; Whole exome sequencing
SDGs
Other Subjects
5 hydroxymethylcytosine; dioxygenase; tet methylcytosine dioxygenase 2; transcription factor EZH2; unclassified drug; adult; aged; allele; animal experiment; animal model; article; ASXL1 gene; cancer prognosis; cell nucleus; cellular distribution; chronic myelomonocytic leukemia; clinical article; controlled study; cytoplasm; Ezh2 gene; female; gene; gene mutation; HEK293 cell line; human; human cell; leukocyte count; male; middle aged; missense mutation; monocyte; mouse; NCSTN gene; nonhuman; oncogene K ras; oncogene N ras; point mutation; priority journal; splenomegaly; survival rate; tet methylcytosine dioxygenase 2 gene; 5hmc; chronic myelomonocytic leukaemia; oncogenic RAS; TET2; whole exome sequencing; Alleles; DNA Mutational Analysis; DNA-Binding Proteins; Epistasis, Genetic; GTP Phosphohydrolases; Humans; Leukemia; Membrane Proteins; Mutation; Prognosis; Proto-Oncogene Proteins
Type
journal article